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Bexarotene induces dyslipidemia by increased very low-density lipoprotein production and cholesteryl ester transfer protein-mediated reduction of high-density lipoprotein.
de Vries-van der Weij J, de Haan W, Hu L, Kuif M, Oei HL, van der Hoorn JW, Havekes LM, Princen HM, Romijn JA, Smit JW, Rensen PC. de Vries-van der Weij J, et al. Endocrinology. 2009 May;150(5):2368-75. doi: 10.1210/en.2008-1540. Epub 2009 Jan 15. Endocrinology. 2009. PMID: 19147676 Clinical Trial.
Pioglitazone decreases plasma cholesteryl ester transfer protein mass, associated with a decrease in hepatic triglyceride content, in patients with type 2 diabetes.
Jonker JT, Wang Y, de Haan W, Diamant M, Rijzewijk LJ, van der Meer RW, Lamb HJ, Tamsma JT, de Roos A, Romijn JA, Rensen PC, Smit JW. Jonker JT, et al. Diabetes Care. 2010 Jul;33(7):1625-8. doi: 10.2337/dc09-1935. Epub 2010 Feb 11. Diabetes Care. 2010. PMID: 20150294 Free PMC article. Clinical Trial.
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity.
Stienstra R, Joosten LA, Koenen T, van Tits B, van Diepen JA, van den Berg SA, Rensen PC, Voshol PJ, Fantuzzi G, Hijmans A, Kersten S, Müller M, van den Berg WB, van Rooijen N, Wabitsch M, Kullberg BJ, van der Meer JW, Kanneganti T, Tack CJ, Netea MG. Stienstra R, et al. Cell Metab. 2010 Dec 1;12(6):593-605. doi: 10.1016/j.cmet.2010.11.011. Cell Metab. 2010. PMID: 21109192 Free PMC article.
Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases plasma CETP and increases apolipoprotein AI levels without improving the cholesterol efflux properties of HDL.
Wang Y, Snel M, Jonker JT, Hammer S, Lamb HJ, de Roos A, Meinders AE, Pijl H, Romijn JA, Smit JW, Jazet IM, Rensen PC. Wang Y, et al. Diabetes Care. 2011 Dec;34(12):2576-80. doi: 10.2337/dc11-0685. Epub 2011 Oct 12. Diabetes Care. 2011. PMID: 21994427 Free PMC article.
393 results