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Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells.
Lachmandas E, Beigier-Bompadre M, Cheng SC, Kumar V, van Laarhoven A, Wang X, Ammerdorffer A, Boutens L, de Jong D, Kanneganti TD, Gresnigt MS, Ottenhoff TH, Joosten LA, Stienstra R, Wijmenga C, Kaufmann SH, van Crevel R, Netea MG. Lachmandas E, et al. Eur J Immunol. 2016 Nov;46(11):2574-2586. doi: 10.1002/eji.201546259. Epub 2016 Sep 27. Eur J Immunol. 2016. PMID: 27624090 Free PMC article.
South Asian men have lower expression of IFN signalling genes in white adipose tissue and skeletal muscle compared with white men.
van Dam AD, Hanssen MJW, van Eenige R, Quinten E, Sips HC, Hülsman CJM, Jazet IM, van Marken Lichtenbelt WD, Ottenhoff THM, Haks MC, Rensen PCN, Boon MR. van Dam AD, et al. Among authors: ottenhoff thm. Diabetologia. 2017 Dec;60(12):2525-2528. doi: 10.1007/s00125-017-4427-8. Epub 2017 Sep 8. Diabetologia. 2017. PMID: 28887664 No abstract available.
Functional Inhibition of Host Histone Deacetylases (HDACs) Enhances in vitro and in vivo Anti-mycobacterial Activity in Human Macrophages and in Zebrafish.
Moreira JD, Koch BEV, van Veen S, Walburg KV, Vrieling F, Mara Pinto Dabés Guimarães T, Meijer AH, Spaink HP, Ottenhoff THM, Haks MC, Heemskerk MT. Moreira JD, et al. Among authors: ottenhoff thm. Front Immunol. 2020 Feb 3;11:36. doi: 10.3389/fimmu.2020.00036. eCollection 2020. Front Immunol. 2020. PMID: 32117228 Free PMC article.
Bioorthogonal Correlative Light-Electron Microscopy of Mycobacterium tuberculosis in Macrophages Reveals the Effect of Antituberculosis Drugs on Subcellular Bacterial Distribution.
Bakkum T, Heemskerk MT, Bos E, Groenewold M, Oikonomeas-Koppasis N, Walburg KV, van Veen S, van der Lienden MJC, van Leeuwen T, Haks MC, Ottenhoff THM, Koster AJ, van Kasteren SI. Bakkum T, et al. Among authors: ottenhoff thm. ACS Cent Sci. 2020 Nov 25;6(11):1997-2007. doi: 10.1021/acscentsci.0c00539. Epub 2020 Oct 16. ACS Cent Sci. 2020. PMID: 33274277 Free PMC article.
511 results