Orcutt KD - Search Results

1

Dosimetry of [²¹²Pb]VMT01, a MC1R-Targeted Alpha Therapeutic Compound, and Effect of Free ²⁰⁸Tl on Tissue Absorbed Doses.

Orcutt KD, Henry KE, Habjan C, Palmer K, Heimann J, Cupido JM, Gottumukkala V, Cissell DD, Lyon MC, Hussein AI, Liu D, Li M, Johnson FL, Schultz MK. Orcutt KD, et al. Molecules. 2022 Sep 8;27(18):5831. doi: 10.3390/molecules27185831. Molecules. 2022. PMID: 36144563 Free PMC article.

2

Optimizing the radiosynthesis of [⁶⁸Ga]DOTA-MLN6907 peptide containing three disulfide cyclization bonds - a GCC specific chelate for clinical radiopharmaceuticals.

Ghai A, Singh B, Li M, Daniels TA, Coelho R, Orcutt K, Watkins GL, Norenberg JP, Cvet D, Schultz MK. Ghai A, et al. Appl Radiat Isot. 2018 Oct;140:333-341. doi: 10.1016/j.apradiso.2018.08.006. Epub 2018 Aug 9. Appl Radiat Isot. 2018. PMID: 30138815

3

A gradient-loadable (64)Cu-chelator for quantifying tumor deposition kinetics of nanoliposomal therapeutics by positron emission tomography.

Lee H, Zheng J, Gaddy D, Orcutt KD, Leonard S, Geretti E, Hesterman J, Harwell C, Hoppin J, Jaffray DA, Wickham T, Hendriks BS, Kirpotin D. Lee H, et al. Among authors: orcutt kd. Nanomedicine. 2015 Jan;11(1):155-65. doi: 10.1016/j.nano.2014.08.011. Epub 2014 Sep 6. Nanomedicine. 2015. PMID: 25200610

4

Dual-Isotope Cryoimaging Quantitative Autoradiography: Investigating Antibody-Drug Conjugate Distribution and Payload Delivery Through Imaging.

Ilovich O, Qutaish M, Hesterman JY, Orcutt K, Hoppin J, Polyak I, Seaman M, Abu-Yousif AO, Cvet D, Bradley DP. Ilovich O, et al. J Nucl Med. 2018 Sep;59(9):1461-1466. doi: 10.2967/jnumed.118.207753. Epub 2018 May 4. J Nucl Med. 2018. PMID: 29728518 Free article.

5

Engineering an antibody with picomolar affinity to DOTA chelates of multiple radionuclides for pretargeted radioimmunotherapy and imaging.

Orcutt KD, Slusarczyk AL, Cieslewicz M, Ruiz-Yi B, Bhushan KR, Frangioni JV, Wittrup KD. Orcutt KD, et al. Nucl Med Biol. 2011 Feb;38(2):223-33. doi: 10.1016/j.nucmedbio.2010.08.013. Epub 2010 Oct 27. Nucl Med Biol. 2011. PMID: 21315278 Free PMC article.

6

Effect of small-molecule-binding affinity on tumor uptake in vivo: a systematic study using a pretargeted bispecific antibody.

Orcutt KD, Rhoden JJ, Ruiz-Yi B, Frangioni JV, Wittrup KD. Orcutt KD, et al. Mol Cancer Ther. 2012 Jun;11(6):1365-72. doi: 10.1158/1535-7163.MCT-11-0764. Epub 2012 Apr 5. Mol Cancer Ther. 2012. PMID: 22491799 Free PMC article.

7

Assessing antibody pharmacokinetics in mice with in vivo imaging.

Hoppin J, Orcutt KD, Hesterman JY, Silva MD, Cheng D, Lackas C, Rusckowski M. Hoppin J, et al. Among authors: orcutt kd. J Pharmacol Exp Ther. 2011 May;337(2):350-8. doi: 10.1124/jpet.110.172916. Epub 2011 Feb 11. J Pharmacol Exp Ther. 2011. PMID: 21317355 Review.

8

Dynamic dual-isotope molecular imaging elucidates principles for optimizing intrathecal drug delivery.

Wolf DA, Hesterman JY, Sullivan JM, Orcutt KD, Silva MD, Lobo M, Wellman T, Hoppin J, Verma A. Wolf DA, et al. Among authors: orcutt kd. JCI Insight. 2016 Feb 25;1(2):e85311. doi: 10.1172/jci.insight.85311. JCI Insight. 2016. PMID: 27699254 Free PMC article.

9

Therapy of Myeloid Leukemia using Novel Bispecific Fusion Proteins Targeting CD45 and ⁹⁰Y-DOTA.

Orozco JJ, Kenoyer AL, Lin Y, O'Steen S, Guel R, Nartea ME, Hernandez AH, Hylarides MD, Fisher DR, Balkin ER, Hamlin DK, Wilbur DS, Orcutt KD, Wittrup KD, Green DJ, Gopal AK, Till BG, Sandmaier B, Press OW, Pagel JM. Orozco JJ, et al. Among authors: orcutt kd. Mol Cancer Ther. 2020 Dec;19(12):2575-2584. doi: 10.1158/1535-7163.MCT-20-0306. Epub 2020 Oct 20. Mol Cancer Ther. 2020. PMID: 33082277 Free PMC article.

10

Molecular Simulation of Receptor Occupancy and Tumor Penetration of an Antibody and Smaller Scaffolds: Application to Molecular Imaging.

Orcutt KD, Adams GP, Wu AM, Silva MD, Harwell C, Hoppin J, Matsumura M, Kotsuma M, Greenberg J, Scott AM, Beckman RA. Orcutt KD, et al. Mol Imaging Biol. 2017 Oct;19(5):656-664. doi: 10.1007/s11307-016-1041-y. Mol Imaging Biol. 2017. PMID: 28213834

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