van Westen GJP - Search Results

1

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion.

van Zwol W, Rimbert A, Wolters JC, Smit M, Bloks VW, Kloosterhuis NJ, Huijkman NCA, Koster MH, Tharehalli U, de Neck SM, Bournez C, Fuh MM, Kuipers J, Rajan S, de Bruin A, Ginsberg HN, van Westen GJP, Hussain MM, Scheja L, Heeren J, Zimmerman P, van de Sluis B, Kuivenhoven JA. van Zwol W, et al. Among authors: van westen gjp, van de sluis b. Hepatology. 2023 Nov 1;78(5):1418-1432. doi: 10.1002/hep.32709. Epub 2022 Oct 12. Hepatology. 2023. PMID: 36053190 Free PMC article.

2

CalcAMP: A New Machine Learning Model for the Accurate Prediction of Antimicrobial Activity of Peptides.

Bournez C, Riool M, de Boer L, Cordfunke RA, de Best L, van Leeuwen R, Drijfhout JW, Zaat SAJ, van Westen GJP. Bournez C, et al. Among authors: van westen gjp, van leeuwen r. Antibiotics (Basel). 2023 Apr 7;12(4):725. doi: 10.3390/antibiotics12040725. Antibiotics (Basel). 2023. PMID: 37107088 Free PMC article.

3

Wang X, Jespers W, de Waal JJ, Wolff KAN, van Uden L, IJzerman AP, van Westen GJP, Heitman LH. Wang X, et al. Among authors: van westen gjp, van uden l. FASEB J. 2022 Jun;36(6):e22358. doi: 10.1096/fj.202200203RR. FASEB J. 2022. PMID: 35604751

4

Cancer-Associated Mutations of the Adenosine A_2A Receptor Have Diverse Influences on Ligand Binding and Receptor Functions.

Feng C, Wang X, Jespers W, Liu R, Zamarbide Losada SD, Gorostiola González M, van Westen GJP, Danen EHJ, Heitman LH. Feng C, et al. Among authors: van westen gjp. Molecules. 2022 Jul 22;27(15):4676. doi: 10.3390/molecules27154676. Molecules. 2022. PMID: 35897852 Free PMC article.

5

Dose escalations in phase I studies: Feasibility of interpreting blinded pharmacodynamic data.

Hassing GJ, van Esdonk MJ, van Westen GJP, Cohen AF, Burggraaf J, Gal P. Hassing GJ, et al. Among authors: van westen gjp, van esdonk mj. Br J Clin Pharmacol. 2022 Dec;88(12):5412-5419. doi: 10.1111/bcp.15473. Epub 2022 Aug 12. Br J Clin Pharmacol. 2022. PMID: 35895751 Free PMC article.

6

Mining protein dynamics from sets of crystal structures using "consensus structures".

van Westen GJ, Wegner JK, Bender A, Ijzerman AP, van Vlijmen HW. van Westen GJ, et al. Protein Sci. 2010 Apr;19(4):742-52. doi: 10.1002/pro.350. Protein Sci. 2010. PMID: 20120021 Free PMC article.

7

Which compound to select in lead optimization? Prospectively validated proteochemometric models guide preclinical development.

van Westen GJ, Wegner JK, Geluykens P, Kwanten L, Vereycken I, Peeters A, Ijzerman AP, van Vlijmen HW, Bender A. van Westen GJ, et al. PLoS One. 2011;6(11):e27518. doi: 10.1371/journal.pone.0027518. Epub 2011 Nov 23. PLoS One. 2011. PMID: 22132107 Free PMC article.

8

Significantly improved HIV inhibitor efficacy prediction employing proteochemometric models generated from antivirogram data.

van Westen GJ, Hendriks A, Wegner JK, Ijzerman AP, van Vlijmen HW, Bender A. van Westen GJ, et al. PLoS Comput Biol. 2013;9(2):e1002899. doi: 10.1371/journal.pcbi.1002899. Epub 2013 Feb 21. PLoS Comput Biol. 2013. PMID: 23436985 Free PMC article.

9

Structure-based identification of OATP1B1/3 inhibitors.

De Bruyn T, van Westen GJ, Ijzerman AP, Stieger B, de Witte P, Augustijns PF, Annaert PP. De Bruyn T, et al. Mol Pharmacol. 2013 Jun;83(6):1257-67. doi: 10.1124/mol.112.084152. Epub 2013 Apr 9. Mol Pharmacol. 2013. PMID: 23571415

10

Benchmarking of protein descriptor sets in proteochemometric modeling (part 1): comparative study of 13 amino acid descriptor sets.

van Westen GJ, Swier RF, Wegner JK, Ijzerman AP, van Vlijmen HW, Bender A. van Westen GJ, et al. J Cheminform. 2013 Sep 23;5(1):41. doi: 10.1186/1758-2946-5-41. J Cheminform. 2013. PMID: 24059694 Free PMC article.

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