Purkiss A - Search Results

1

CCP4 Cloud for structure determination and project management in macromolecular crystallography.

Krissinel E, Lebedev AA, Uski V, Ballard CB, Keegan RM, Kovalevskiy O, Nicholls RA, Pannu NS, Skubák P, Berrisford J, Fando M, Lohkamp B, Wojdyr M, Simpkin AJ, Thomas JMH, Oliver C, Vonrhein C, Chojnowski G, Basle A, Purkiss A, Isupov MN, McNicholas S, Lowe E, Triviño J, Cowtan K, Agirre J, Rigden DJ, Uson I, Lamzin V, Tews I, Bricogne G, Leslie AGW, Brown DG. Krissinel E, et al. Among authors: purkiss a. Acta Crystallogr D Struct Biol. 2022 Sep 1;78(Pt 9):1079-1089. doi: 10.1107/S2059798322007987. Epub 2022 Aug 30. Acta Crystallogr D Struct Biol. 2022. PMID: 36048148 Free PMC article.

2

Association of circulating TNF-alpha and IL-6 with ageing and parkinsonism.

Dobbs RJ, Charlett A, Purkiss AG, Dobbs SM, Weller C, Peterson DW. Dobbs RJ, et al. Among authors: purkiss ag. Acta Neurol Scand. 1999 Jul;100(1):34-41. doi: 10.1111/j.1600-0404.1999.tb00721.x. Acta Neurol Scand. 1999. PMID: 10416510

3

Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of R_p- and S_p-dNTPαS Diastereomers.

Morris ER, Kunzelmann S, Caswell SJ, Purkiss AG, Kelly G, Taylor IA. Morris ER, et al. Among authors: purkiss ag. Biochemistry. 2021 Jun 1;60(21):1682-1698. doi: 10.1021/acs.biochem.0c00944. Epub 2021 May 14. Biochemistry. 2021. PMID: 33988981 Free PMC article.

4

A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing.

Adams SE, Purkiss AG, Knowles PP, Nans A, Briggs DC, Borg A, Earl CP, Goodman KM, Nawrotek A, Borg AJ, McIntosh PB, Houghton FM, Kjær S, McDonald NQ. Adams SE, et al. Among authors: purkiss ag. Structure. 2021 Jul 1;29(7):694-708.e7. doi: 10.1016/j.str.2020.12.012. Epub 2021 Jan 22. Structure. 2021. PMID: 33484636 Free PMC article.

5

IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties.

Dagil R, Ball NJ, Ogrodowicz RW, Hobor F, Purkiss AG, Kelly G, Martin SR, Taylor IA, Ramos A. Dagil R, et al. Among authors: purkiss ag. Nucleic Acids Res. 2019 May 7;47(8):4334-4348. doi: 10.1093/nar/gkz136. Nucleic Acids Res. 2019. PMID: 30864660 Free PMC article.

6

D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition.

de Chiara C, Homšak M, Prosser GA, Douglas HL, Garza-Garcia A, Kelly G, Purkiss AG, Tate EW, de Carvalho LPS. de Chiara C, et al. Among authors: purkiss ag. Nat Chem Biol. 2020 Jun;16(6):686-694. doi: 10.1038/s41589-020-0498-9. Epub 2020 Mar 16. Nat Chem Biol. 2020. PMID: 32203411 Free PMC article.

7

Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Morris ER, Caswell SJ, Kunzelmann S, Arnold LH, Purkiss AG, Kelly G, Taylor IA. Morris ER, et al. Among authors: purkiss ag. Nat Commun. 2020 Jun 23;11(1):3165. doi: 10.1038/s41467-020-16983-2. Nat Commun. 2020. PMID: 32576829 Free PMC article.

8

Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon.

Kostelecky B, Saurin AT, Purkiss A, Parker PJ, McDonald NQ. Kostelecky B, et al. Among authors: purkiss a. EMBO Rep. 2009 Sep;10(9):983-9. doi: 10.1038/embor.2009.150. Epub 2009 Aug 7. EMBO Rep. 2009. PMID: 19662078 Free PMC article.

9

Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes.

Kjær S, Linch M, Purkiss A, Kostelecky B, Knowles PP, Rosse C, Riou P, Soudy C, Kaye S, Patel B, Soriano E, Murray-Rust J, Barton C, Dillon C, Roffey J, Parker PJ, McDonald NQ. Kjær S, et al. Among authors: purkiss a. Biochem J. 2013 Apr 15;451(2):329-42. doi: 10.1042/BJ20121871. Biochem J. 2013. PMID: 23418854

10

14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins.

Riou P, Kjær S, Garg R, Purkiss A, George R, Cain RJ, Bineva G, Reymond N, McColl B, Thompson AJ, O'Reilly N, McDonald NQ, Parker PJ, Ridley AJ. Riou P, et al. Among authors: purkiss a. Cell. 2013 Apr 25;153(3):640-53. doi: 10.1016/j.cell.2013.03.044. Cell. 2013. PMID: 23622247 Free PMC article.

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