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Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCs.
Brighi C, Salaris F, Soloperto A, Cordella F, Ghirga S, de Turris V, Rosito M, Porceddu PF, D'Antoni C, Reggiani A, Rosa A, Di Angelantonio S. Brighi C, et al. Among authors: reggiani a. Cell Death Dis. 2021 May 15;12(5):498. doi: 10.1038/s41419-021-03776-8. Cell Death Dis. 2021. PMID: 33993189 Free PMC article.
The mood stabilizing properties of AF3581, a novel potent GSK-3β inhibitor.
Capurro V, Lanfranco M, Summa M, Porceddu PF, Ciampoli M, Margaroli N, Durando L, Garrone B, Ombrato R, Tongiani S, Reggiani A. Capurro V, et al. Among authors: reggiani a. Biomed Pharmacother. 2020 Aug;128:110249. doi: 10.1016/j.biopha.2020.110249. Epub 2020 May 26. Biomed Pharmacother. 2020. PMID: 32470749 Free article.
Optimization of Indazole-Based GSK-3 Inhibitors with Mitigated hERG Issue and In Vivo Activity in a Mood Disorder Model.
Prati F, Buonfiglio R, Furlotti G, Cavarischia C, Mangano G, Picollo R, Oggianu L, di Matteo A, Olivieri S, Bovi G, Porceddu PF, Reggiani A, Garrone B, Di Giorgio FP, Ombrato R. Prati F, et al. Among authors: reggiani a. ACS Med Chem Lett. 2020 Mar 24;11(5):825-831. doi: 10.1021/acsmedchemlett.9b00633. eCollection 2020 May 14. ACS Med Chem Lett. 2020. PMID: 32435391 Free PMC article.
Hit Optimization of 5-Substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) Inhibitors with in Vivo Activity in Model of Mood Disorders.
Furlotti G, Alisi MA, Cazzolla N, Dragone P, Durando L, Magarò G, Mancini F, Mangano G, Ombrato R, Vitiello M, Armirotti A, Capurro V, Lanfranco M, Ottonello G, Summa M, Reggiani A. Furlotti G, et al. Among authors: reggiani a. J Med Chem. 2015 Nov 25;58(22):8920-37. doi: 10.1021/acs.jmedchem.5b01208. Epub 2015 Nov 13. J Med Chem. 2015. PMID: 26486317
A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation.
Ribeiro A, Pontis S, Mengatto L, Armirotti A, Chiurchiù V, Capurro V, Fiasella A, Nuzzi A, Romeo E, Moreno-Sanz G, Maccarrone M, Reggiani A, Tarzia G, Mor M, Bertozzi F, Bandiera T, Piomelli D. Ribeiro A, et al. Among authors: reggiani a. ACS Chem Biol. 2015 Aug 21;10(8):1838-46. doi: 10.1021/acschembio.5b00114. Epub 2015 Apr 15. ACS Chem Biol. 2015. PMID: 25874594 Free PMC article.
Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration.
Di Fruscia P, Carbone A, Bottegoni G, Berti F, Giacomina F, Ponzano S, Pagliuca C, Fiasella A, Pizzirani D, Ortega JA, Nuzzi A, Tarozzo G, Mengatto L, Giampà R, Penna I, Russo D, Romeo E, Summa M, Bertorelli R, Armirotti A, Bertozzi SM, Reggiani A, Bandiera T, Bertozzi F. Di Fruscia P, et al. Among authors: reggiani a. J Med Chem. 2021 Sep 23;64(18):13327-13355. doi: 10.1021/acs.jmedchem.1c00575. Epub 2021 Sep 1. J Med Chem. 2021. PMID: 34469137 Free PMC article.
240 results