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Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01.
Sinha S, Du Z, Maiti P, Klärner FG, Schrader T, Wang C, Bitan G. Sinha S, et al. ACS Chem Neurosci. 2012 Jun 20;3(6):451-8. doi: 10.1021/cn200133x. Epub 2012 Mar 7. ACS Chem Neurosci. 2012. PMID: 22860214 Free PMC article.
Many compounds have been tested as inhibitors or modulators of amyloid beta-protein (Abeta) assembly in hope that they would lead to effective, disease-modifying therapy for Alzheimer's disease (AD). These compounds typically were either designed to break apart beta-sheets …
Many compounds have been tested as inhibitors or modulators of amyloid beta-protein (Abeta) assembly in hope that they would lead to effecti …
A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.
Prabhudesai S, Sinha S, Attar A, Kotagiri A, Fitzmaurice AG, Lakshmanan R, Ivanova MI, Loo JA, Klärner FG, Schrader T, Stahl M, Bitan G, Bronstein JM. Prabhudesai S, et al. Among authors: sinha s. Neurotherapeutics. 2012 Apr;9(2):464-76. doi: 10.1007/s13311-012-0105-1. Neurotherapeutics. 2012. PMID: 22373667 Free PMC article.
Rational design of β-sheet ligands against Aβ42-induced toxicity.
Hochdörffer K, März-Berberich J, Nagel-Steger L, Epple M, Meyer-Zaika W, Horn AH, Sticht H, Sinha S, Bitan G, Schrader T. Hochdörffer K, et al. Among authors: sinha s. J Am Chem Soc. 2011 Mar 30;133(12):4348-58. doi: 10.1021/ja107675n. Epub 2011 Mar 7. J Am Chem Soc. 2011. PMID: 21381732
Bronchom assuages airway hyperresponsiveness in house dust mite-induced mouse model of allergic asthma and moderates goblet cell metaplasia, sub-epithelial fibrosis along with changes in Th2 cytokines and chemokines.
Balkrishna A, Sinha S, Karumuri S, Maity M, Dev R, Varshney A. Balkrishna A, et al. Among authors: sinha s. Front Immunol. 2024 May 14;15:1384697. doi: 10.3389/fimmu.2024.1384697. eCollection 2024. Front Immunol. 2024. PMID: 38807596 Free PMC article.
Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of cell cycle.
Johnson CS, Williams MJ, Sham K, Belluschi S, Ma W, Wang X, Lau WW, Kaufmann K, Krivdova G, Calderbank EF, Mende N, McLeod J, Mantica G, Li J, Grey-Wilson C, Drakopoulos M, Basheer S, Sinha S, Diamanti E, Basford C, Wilson NK, Howe SJ, Dick JE, Gottgens B, Green AR, Francis N, Laurenti E PhD. Johnson CS, et al. Among authors: sinha s. Blood. 2024 May 28:blood.2023021426. doi: 10.1182/blood.2023021426. Online ahead of print. Blood. 2024. PMID: 38805639
6,515 results