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β-catenin cancer-enhancing genomic regions axis is involved in the development of fibrolamellar hepatocellular carcinoma.
Gulati R, Johnston M, Rivas M, Cast A, Kumbaji M, Hanlon MA, Lee S, Zhou P, Lake C, Schepers E, Min KW, Yoon JH, Karns R, Reid LM, Lopez-Terrada D, Timchenko L, Parameswaran S, Weirauch MT, Ranganathan S, Bondoc A, Geller J, Tiao G, Shin S, Timchenko N. Gulati R, et al. Among authors: karns r. Hepatol Commun. 2022 Oct;6(10):2950-2963. doi: 10.1002/hep4.2055. Epub 2022 Aug 24. Hepatol Commun. 2022. PMID: 36000549 Free PMC article.
FXR-Gankyrin axis is involved in development of pediatric liver cancer.
Valanejad L, Lewis K, Wright M, Jiang Y, D'Souza A, Karns R, Sheridan R, Gupta A, Bove K, Witte D, Geller J, Tiao G, Nelson DL, Timchenko L, Timchenko N. Valanejad L, et al. Among authors: karns r. Carcinogenesis. 2017 Jul 1;38(7):738-747. doi: 10.1093/carcin/bgx050. Carcinogenesis. 2017. PMID: 28535186 Free PMC article.
Correction of GSK3β at young age prevents muscle pathology in mice with myotonic dystrophy type 1.
Wei C, Stock L, Valanejad L, Zalewski ZA, Karns R, Puymirat J, Nelson D, Witte D, Woodgett J, Timchenko NA, Timchenko L. Wei C, et al. Among authors: karns r. FASEB J. 2018 Apr;32(4):2073-2085. doi: 10.1096/fj.201700700R. Epub 2018 Jan 5. FASEB J. 2018. PMID: 29203592 Free PMC article.
These findings suggest that the correction of GSK3beta-CUGBP1 pathway in young HSA(LR) mice might have a positive effect on the myogenesis over time.-Wei, C., Stock, L., Valanejad, L., Zalewski, Z. A., Karns, R., Puymirat, J., Nelson, D., Witte, D., Woodgett, J., Ti …
These findings suggest that the correction of GSK3beta-CUGBP1 pathway in young HSA(LR) mice might have a positive effect on the myogenesis o …
Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation.
D'Souza AM, Jiang Y, Cast A, Valanejad L, Wright M, Lewis K, Kumbaji M, Shah S, Smithrud D, Karns R, Shin S, Timchenko N. D'Souza AM, et al. Among authors: karns r. Cell Mol Gastroenterol Hepatol. 2018 May 24;6(3):239-255. doi: 10.1016/j.jcmgh.2018.05.007. eCollection 2018. Cell Mol Gastroenterol Hepatol. 2018. PMID: 30109252 Free PMC article.
Type I interferon sensing unlocks dormant adipocyte inflammatory potential.
Chan CC, Damen MSMA, Moreno-Fernandez ME, Stankiewicz TE, Cappelletti M, Alarcon PC, Oates JR, Doll JR, Mukherjee R, Chen X, Karns R, Weirauch MT, Helmrath MA, Inge TH, Divanovic S. Chan CC, et al. Among authors: karns r. Nat Commun. 2020 Jun 2;11(1):2745. doi: 10.1038/s41467-020-16571-4. Nat Commun. 2020. PMID: 32488081 Free PMC article.
97 results