Overexpressed Cyclin D1 and CDK4 proteins are responsible for the resistance to CDK4/6 inhibitor in breast cancer that can be reversed by PI3K/mTOR inhibitors.
Cai Z, Wang J, Li Y, Shi Q, Jin L, Li S, Zhu M, Wang Q, Wong LL, Yang W, Lai H, Gong C, Yao Y, Liu Y, Zhang J, Yao H, Liu Q.
Cai Z, et al. Among authors: wang j, wang q.
Sci China Life Sci. 2023 Jan;66(1):94-109. doi: 10.1007/s11427-021-2140-8. Epub 2022 Aug 11.
Sci China Life Sci. 2023.
PMID: 35982377