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Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations.
Rae W, Sowerby JM, Verhoeven D, Youssef M, Kotagiri P, Savinykh N, Coomber EL, Boneparth A, Chan A, Gong C, Jansen MH, du Long R, Santilli G, Simeoni I, Stephens J, Wu K, Zinicola M, Allen HL, Baxendale H, Kumararatne D, Gkrania-Klotsas E, Scheffler Mendoza SC, Yamazaki-Nakashimada MA, Ruiz LB, Rojas-Maruri CM, Lugo Reyes SO, Lyons PA, Williams AP, Hodson DJ, Bishop GA, Thrasher AJ, Thomas DC, Murphy MP, Vyse TJ, Milner JD, Kuijpers TW, Smith KGC. Rae W, et al. Among authors: murphy mp. Sci Immunol. 2022 Aug 12;7(74):eabn3800. doi: 10.1126/sciimmunol.abn3800. Epub 2022 Aug 12. Sci Immunol. 2022. PMID: 35960817
How mitochondrial damage affects cell function.
James AM, Murphy MP. James AM, et al. Among authors: murphy mp. J Biomed Sci. 2002;9(6 Pt 1):475-87. doi: 10.1159/000064721. J Biomed Sci. 2002. PMID: 12372986 Review.
Glycolysis promotes caspase-3 activation in lipid rafts in T cells.
Secinaro MA, Fortner KA, Dienz O, Logan A, Murphy MP, Anathy V, Boyson JE, Budd RC. Secinaro MA, et al. Among authors: murphy mp. Cell Death Dis. 2018 Jan 19;9(2):62. doi: 10.1038/s41419-017-0099-z. Cell Death Dis. 2018. PMID: 29352186 Free PMC article.
mtDNA mutations help support cancer cells.
Prag HA, Murphy MP. Prag HA, et al. Among authors: murphy mp. Nat Cancer. 2020 Oct;1(10):941-942. doi: 10.1038/s43018-020-00128-x. Nat Cancer. 2020. PMID: 35121873 No abstract available.
Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease.
Wiegman CH, Michaeloudes C, Haji G, Narang P, Clarke CJ, Russell KE, Bao W, Pavlidis S, Barnes PJ, Kanerva J, Bittner A, Rao N, Murphy MP, Kirkham PA, Chung KF, Adcock IM; COPDMAP. Wiegman CH, et al. Among authors: murphy mp. J Allergy Clin Immunol. 2015 Sep;136(3):769-80. doi: 10.1016/j.jaci.2015.01.046. Epub 2015 Mar 29. J Allergy Clin Immunol. 2015. PMID: 25828268 Free PMC article.
How should we talk about metabolism?
Murphy MP, O'Neill LAJ. Murphy MP, et al. Nat Immunol. 2020 Jul;21(7):713-715. doi: 10.1038/s41590-020-0691-8. Nat Immunol. 2020. PMID: 32409776 No abstract available.
Mitochondrial complex I activity in microglia sustains neuroinflammation.
Peruzzotti-Jametti L, Willis CM, Krzak G, Hamel R, Pirvan L, Ionescu RB, Reisz JA, Prag HA, Garcia-Segura ME, Wu V, Xiang Y, Barlas B, Casey AM, van den Bosch AMR, Nicaise AM, Roth L, Bates GR, Huang H, Prasad P, Vincent AE, Frezza C, Viscomi C, Balmus G, Takats Z, Marioni JC, D'Alessandro A, Murphy MP, Mohorianu I, Pluchino S. Peruzzotti-Jametti L, et al. Among authors: murphy mp. Nature. 2024 Apr;628(8006):195-203. doi: 10.1038/s41586-024-07167-9. Epub 2024 Mar 13. Nature. 2024. PMID: 38480879 Free PMC article.
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