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Intrinsic Folding Properties of the HLA-B27 Heavy Chain Revealed by Single Chain Trimer Versions of Peptide-Loaded Class I Major Histocompatibility Complex Molecules.
Lenart I, Truong LH, Nguyen DD, Rasiukienė O, Tsao E, Armstrong J, Kumar P, McHugh K, Pereira BI, Maan BS, Garstka MA, Bowness P, Blake N, Powis SJ, Gould K, Nesbeth D, Antoniou AN. Lenart I, et al. Among authors: mchugh k. Front Immunol. 2022 Jul 25;13:902135. doi: 10.3389/fimmu.2022.902135. eCollection 2022. Front Immunol. 2022. PMID: 35958592 Free PMC article.
KIR3DL2 binds to HLA-B27 dimers and free H chains more strongly than other HLA class I and promotes the expansion of T cells in ankylosing spondylitis.
Wong-Baeza I, Ridley A, Shaw J, Hatano H, Rysnik O, McHugh K, Piper C, Brackenbridge S, Fernandes R, Chan A, Bowness P, Kollnberger S. Wong-Baeza I, et al. Among authors: mchugh k. J Immunol. 2013 Apr 1;190(7):3216-24. doi: 10.4049/jimmunol.1202926. Epub 2013 Feb 25. J Immunol. 2013. PMID: 23440420 Free PMC article.
The arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09.
Cauli A, Shaw J, Giles J, Hatano H, Rysnik O, Payeli S, McHugh K, Dessole G, Porru G, Desogus E, Fiedler S, Hölper S, Carette A, Blanco-Gelaz MA, Vacca A, Piga M, Ibba V, Garau P, La Nasa G, López-Larrea C, Mathieu A, Renner C, Bowness P, Kollnberger S. Cauli A, et al. Among authors: mchugh k. Rheumatology (Oxford). 2013 Nov;52(11):1952-62. doi: 10.1093/rheumatology/ket219. Epub 2013 Jun 26. Rheumatology (Oxford). 2013. PMID: 23804219 Free PMC article.
569 results