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Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases.
Cell. 2022 Aug 18;185(17):3232-3247.e18. doi: 10.1016/j.cell.2022.06.048. Epub 2022 Aug 10.
Cell. 2022.
PMID: 35952671
Free PMC article.
Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140.
Mehta S, Cronkite DA, Basavappa M, Saunders TL, Adiliaghdam F, Amatullah H, Morrison SA, Pagan JD, Anthony RM, Tonnerre P, Lauer GM, Lee JC, Digumarthi S, Pantano L, Ho Sui SJ, Ji F, Sadreyev R, Zhou C, Mullen AC, Kumar V, Li Y, Wijmenga C, Xavier RJ, Means TK, Jeffrey KL.
Mehta S, et al. Among authors: digumarthi s.
Sci Immunol. 2017 Mar 3;2(9):eaag3160. doi: 10.1126/sciimmunol.aag3160. Epub 2017 Mar 3.
Sci Immunol. 2017.
PMID: 28783698
Free PMC article.
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Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation.
Adiliaghdam F, Amatullah H, Digumarthi S, Saunders TL, Rahman RU, Wong LP, Sadreyev R, Droit L, Paquette J, Goyette P, Rioux JD, Hodin R, Mihindukulasuriya KA, Handley SA, Jeffrey KL.
Adiliaghdam F, et al. Among authors: digumarthi s.
Sci Immunol. 2022 Apr 8;7(70):eabn6660. doi: 10.1126/sciimmunol.abn6660. Epub 2022 Apr 8.
Sci Immunol. 2022.
PMID: 35394816
Free PMC article.
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Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation.
Arifuzzaman M, Won TH, Li TT, Yano H, Digumarthi S, Heras AF, Zhang W, Parkhurst CN, Kashyap S, Jin WB, Putzel GG, Tsou AM, Chu C, Wei Q, Grier A; JRI IBD Live Cell Bank Consortium; Worgall S, Guo CJ, Schroeder FC, Artis D.
Arifuzzaman M, et al. Among authors: digumarthi s.
Nature. 2022 Nov;611(7936):578-584. doi: 10.1038/s41586-022-05380-y. Epub 2022 Nov 2.
Nature. 2022.
PMID: 36323778
Free PMC article.
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