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Suppression of trimethylamine N-oxide with DMB mitigates vascular dysfunction, exercise intolerance, and frailty associated with a Western-style diet in mice.
J Appl Physiol (1985). 2022 Oct 1;133(4):798-813. doi: 10.1152/japplphysiol.00350.2022. Epub 2022 Aug 11.
J Appl Physiol (1985). 2022.
PMID: 35952350
Free PMC article.
Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans.
Brunt VE, Gioscia-Ryan RA, Casso AG, VanDongen NS, Ziemba BP, Sapinsley ZJ, Richey JJ, Zigler MC, Neilson AP, Davy KP, Seals DR.
Brunt VE, et al. Among authors: sapinsley zj.
Hypertension. 2020 Jul;76(1):101-112. doi: 10.1161/HYPERTENSIONAHA.120.14759. Epub 2020 Jun 10.
Hypertension. 2020.
PMID: 32520619
Free PMC article.
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The gut microbiome-derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging.
Brunt VE, LaRocca TJ, Bazzoni AE, Sapinsley ZJ, Miyamoto-Ditmon J, Gioscia-Ryan RA, Neilson AP, Link CD, Seals DR.
Brunt VE, et al. Among authors: sapinsley zj.
Geroscience. 2021 Feb;43(1):377-394. doi: 10.1007/s11357-020-00257-2. Epub 2020 Aug 29.
Geroscience. 2021.
PMID: 32862276
Free PMC article.
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Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans.
Brunt VE, Casso AG, Gioscia-Ryan RA, Sapinsley ZJ, Ziemba BP, Clayton ZS, Bazzoni AE, VanDongen NS, Richey JJ, Hutton DA, Zigler MC, Neilson AP, Davy KP, Seals DR.
Brunt VE, et al. Among authors: sapinsley zj.
Hypertension. 2021 Aug;78(2):499-511. doi: 10.1161/HYPERTENSIONAHA.120.16895. Epub 2021 May 10.
Hypertension. 2021.
PMID: 33966451
Free PMC article.
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Short-term interleukin-37 treatment improves vascular endothelial function, endurance exercise capacity, and whole-body glucose metabolism in old mice.
Ballak DB, Brunt VE, Sapinsley ZJ, Ziemba BP, Richey JJ, Zigler MC, Johnson LC, Gioscia-Ryan RA, Culp-Hill R, Eisenmesser EZ, D'Alessandro A, Dinarello CA, Seals DR.
Ballak DB, et al. Among authors: sapinsley zj.
Aging Cell. 2020 Jan;19(1):e13074. doi: 10.1111/acel.13074. Epub 2019 Nov 21.
Aging Cell. 2020.
PMID: 31755162
Free PMC article.
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