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OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy.
Yamamoto H, Nagumo Y, Ishikawa Y, Irukayama-Tomobe Y, Namekawa Y, Nemoto T, Tanaka H, Takahashi G, Tokuda A, Saitoh T, Nagase H, Funato H, Yanagisawa M. Yamamoto H, et al. Among authors: yanagisawa m. PLoS One. 2022 Jul 22;17(7):e0271901. doi: 10.1371/journal.pone.0271901. eCollection 2022. PLoS One. 2022. PMID: 35867683 Free PMC article.
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.
Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M. Sakurai T, et al. Among authors: yanagisawa m. Cell. 1998 Feb 20;92(4):573-85. doi: 10.1016/s0092-8674(00)80949-6. Cell. 1998. PMID: 9491897 Free article.
Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.
Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB, Yanagisawa M. Chemelli RM, et al. Among authors: yanagisawa m. Cell. 1999 Aug 20;98(4):437-51. doi: 10.1016/s0092-8674(00)81973-x. Cell. 1999. PMID: 10481909 Free article.
Endothelin-1 stimulates leptin production in adipocytes.
Xiong Y, Tanaka H, Richardson JA, Williams SC, Slaughter CA, Nakamura M, Chen JL, Yanagisawa M. Xiong Y, et al. Among authors: yanagisawa m. J Biol Chem. 2001 Jul 27;276(30):28471-7. doi: 10.1074/jbc.M103478200. Epub 2001 May 18. J Biol Chem. 2001. PMID: 11359784 Free article.
Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes.
Willie JT, Chemelli RM, Sinton CM, Tokita S, Williams SC, Kisanuki YY, Marcus JN, Lee C, Elmquist JK, Kohlmeier KA, Leonard CS, Richardson JA, Hammer RE, Yanagisawa M. Willie JT, et al. Among authors: yanagisawa m. Neuron. 2003 Jun 5;38(5):715-30. doi: 10.1016/s0896-6273(03)00330-1. Neuron. 2003. PMID: 12797957 Free article.
1,178 results