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Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine.
Singh AK, De Wijngaert B, Bijnens M, Uyttersprot K, Nguyen H, Martinez SE, Schols D, Herdewijn P, Pannecouque C, Arnold E, Das K. Singh AK, et al. Among authors: schols d. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2203660119. doi: 10.1073/pnas.2203660119. Epub 2022 Jul 19. Proc Natl Acad Sci U S A. 2022. PMID: 35858448 Free PMC article.
Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase.
Pauwels R, Andries K, Debyser Z, Van Daele P, Schols D, Stoffels P, De Vreese K, Woestenborghs R, Vandamme AM, Janssen CG, et al. Pauwels R, et al. Among authors: schols d. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1711-5. doi: 10.1073/pnas.90.5.1711. Proc Natl Acad Sci U S A. 1993. PMID: 7680476 Free PMC article.
SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus.
Witvrouw M, Balzarini J, Pannecouque C, Jhaumeer-Laulloo S, Esté JA, Schols D, Cherepanov P, Schmit JC, Debyser Z, Vandamme AM, Desmyter J, Ramadas SR, de Clercq E. Witvrouw M, et al. Among authors: schols d. Antimicrob Agents Chemother. 1997 Feb;41(2):262-8. doi: 10.1128/AAC.41.2.262. Antimicrob Agents Chemother. 1997. PMID: 9021177 Free PMC article.
Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle.
Witvrouw M, Fikkert V, Pluymers W, Matthews B, Mardel K, Schols D, Raff J, Debyser Z, De Clercq E, Holan G, Pannecouque C. Witvrouw M, et al. Among authors: schols d. Mol Pharmacol. 2000 Nov;58(5):1100-8. Mol Pharmacol. 2000. PMID: 11040059
484 results