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Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic viruses.
Yan J, Chen Y, Patel AJ, Warda S, Lee CJ, Nixon BG, Wong EW, Miranda-Román MA, Yang N, Wang Y, Pachai MR, Sher J, Giff E, Tang F, Khurana E, Singer S, Liu Y, Galbo PM Jr, Maag JL, Koche RP, Zheng D, Antonescu CR, Deng L, Li MO, Chen Y, Chi P. Yan J, et al. Among authors: deng l. J Clin Invest. 2022 Sep 1;132(17):e153437. doi: 10.1172/JCI153437. J Clin Invest. 2022. PMID: 35852856 Free PMC article.
In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response.
Sahu A, Kose K, Kraehenbuehl L, Byers C, Holland A, Tembo T, Santella A, Alfonso A, Li M, Cordova M, Gill M, Fox C, Gonzalez S, Kumar P, Wang AW, Kurtansky N, Chandrani P, Yin S, Mehta P, Navarrete-Dechent C, Peterson G, King K, Dusza S, Yang N, Liu S, Phillips W, Guitera P, Rossi A, Halpern A, Deng L, Pulitzer M, Marghoob A, Chen CJ, Merghoub T, Rajadhyaksha M. Sahu A, et al. Among authors: deng l. Nat Commun. 2022 Sep 9;13(1):5312. doi: 10.1038/s41467-022-32738-7. Nat Commun. 2022. PMID: 36085288 Free PMC article.
Vaccinia E5 is a major inhibitor of the DNA sensor cGAS.
Yang N, Wang Y, Dai P, Li T, Zierhut C, Tan A, Zhang T, Xiang JZ, Ordureau A, Funabiki H, Chen Z, Deng L. Yang N, et al. Among authors: deng l. Nat Commun. 2023 May 22;14(1):2898. doi: 10.1038/s41467-023-38514-5. Nat Commun. 2023. PMID: 37217469 Free PMC article.
Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma.
Budhu S, Giese R, Gupta A, Fitzgerald K, Zappasodi R, Schad S, Hirschhorn D, Campesato LF, De Henau O, Gigoux M, Liu C, Mazo G, Deng L, Barker CA, Wolchok JD, Merghoub T. Budhu S, et al. Among authors: deng l. Cell Rep. 2021 Jan 12;34(2):108620. doi: 10.1016/j.celrep.2020.108620. Cell Rep. 2021. PMID: 33440157 Free PMC article.
8,056 results