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Safety and efficacy of the 5-lipoxygenase-activating protein inhibitor AZD5718 in patients with recent myocardial infarction: The phase 2a FLAVOUR study.
Prescott E, Angerås O, Erlinge D, Grove EL, Hedman M, Jensen LO, Pernow J, Saraste A, Åkerblom A, Svedlund S, Rudvik A, Knöchel J, Lindstedt EL, Garkaviy P, Gan LM, Gabrielsen A. Prescott E, et al. Among authors: gabrielsen a. Int J Cardiol. 2022 Oct 15;365:34-40. doi: 10.1016/j.ijcard.2022.07.016. Epub 2022 Jul 14. Int J Cardiol. 2022. PMID: 35842004 Free article. Clinical Trial.
Pharmacokinetics, Pharmacodynamics, and Tolerability of AZD5718, an Oral 5-Lipoxygenase-Activating Protein (FLAP) Inhibitor, in Healthy Japanese Male Subjects.
Knöchel J, Nelander K, Heijer M, Lindstedt EL, Forsberg GB, Whatling C, Shimada H, Han DS, Gabrielsen A, Garkaviy P, Ericsson H. Knöchel J, et al. Among authors: gabrielsen a. Clin Drug Investig. 2021 Oct;41(10):895-905. doi: 10.1007/s40261-021-01078-7. Epub 2021 Sep 21. Clin Drug Investig. 2021. PMID: 34546534 Free PMC article. Clinical Trial.
Arginase 1 is upregulated at admission in patients with ST-elevation myocardial infarction.
Tengbom J, Cederström S, Verouhis D, Böhm F, Eriksson P, Folkersen L, Gabrielsen A, Jernberg T, Lundman P, Persson J, Saleh N, Settergren M, Sörensson P, Tratsiakovich Y, Tornvall P, Jung C, Pernow J. Tengbom J, et al. Among authors: gabrielsen a. J Intern Med. 2021 Nov;290(5):1061-1070. doi: 10.1111/joim.13358. Epub 2021 Aug 23. J Intern Med. 2021. PMID: 34237174 Free article.
Effect of AZD9977 and spironolactone on serum potassium in heart failure with preserved or mildly reduced ejection fraction, and renal impairment: A randomized trial.
Squire IB, Gabrielsen A, Greasley PJ, Wernevik L, Hartleib-Geschwindner J, Holden J, Johansson S, Rudvik A, Sánchez J, Bamberg K, Melin J, Whittaker A. Squire IB, et al. Among authors: gabrielsen a. Clin Transl Sci. 2022 Oct;15(10):2493-2504. doi: 10.1111/cts.13377. Epub 2022 Aug 20. Clin Transl Sci. 2022. PMID: 35971596 Free PMC article. Clinical Trial.
Endothelin-1 increases expression and activity of arginase 2 via ETB receptors and is co-expressed with arginase 2 in human atherosclerotic plaques.
Rafnsson A, Matic LP, Lengquist M, Mahdi A, Shemyakin A, Paulsson-Berne G, Hansson GK, Gabrielsen A, Hedin U, Yang J, Pernow J. Rafnsson A, et al. Among authors: gabrielsen a. Atherosclerosis. 2020 Jan;292:215-223. doi: 10.1016/j.atherosclerosis.2019.09.020. Epub 2019 Oct 1. Atherosclerosis. 2020. PMID: 31606133
New candidate genes for ST-elevation myocardial infarction.
Cederström S, Lundman P, Folkersen L, Paulsson-Berne G, Karadimou G, Eriksson P, Caidahl K, Gabrielsen A, Jernberg T, Persson J, Tornvall P. Cederström S, et al. Among authors: gabrielsen a. J Intern Med. 2020 Jan;287(1):66-77. doi: 10.1111/joim.12976. Epub 2019 Oct 7. J Intern Med. 2020. PMID: 31589004 Free article.
Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability.
Qiu H, Gabrielsen A, Agardh HE, Wan M, Wetterholm A, Wong CH, Hedin U, Swedenborg J, Hansson GK, Samuelsson B, Paulsson-Berne G, Haeggström JZ. Qiu H, et al. Among authors: gabrielsen a. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8161-6. doi: 10.1073/pnas.0602414103. Epub 2006 May 12. Proc Natl Acad Sci U S A. 2006. PMID: 16698924 Free PMC article.
173 results