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ATF2 loss promotes tumor invasion in colorectal cancer cells via upregulation of cancer driver TROP2.
Huebner K, Erlenbach-Wuensch K, Prochazka J, Sheraj I, Hampel C, Mrazkova B, Michalcikova T, Tureckova J, Iatsiuk V, Weissmann A, Ferrazzi F, Kunze P, Nalli E, Sammer E, Gehring A, Cheema MM, Eckstein M, Paap EM, Soederberg A, Fischer C, Paul S, Mahadevan V, Ndreshkjana B, Meier MA, Muehlich S, Geppert CI, Merkel S, Grutzmann R, Roehe A, Banerjee S, Hartmann A, Sedlacek R, Schneider-Stock R. Huebner K, et al. Among authors: muehlich s. Cell Mol Life Sci. 2022 Jul 15;79(8):423. doi: 10.1007/s00018-022-04445-5. Cell Mol Life Sci. 2022. PMID: 35838828 Free PMC article.
Inhibition of TRPM7 blocks MRTF/SRF-dependent transcriptional and tumorigenic activity.
Voringer S, Schreyer L, Nadolni W, Meier MA, Woerther K, Mittermeier C, Ferioli S, Singer S, Holzer K, Zierler S, Chubanov V, Liebl B, Gudermann T, Muehlich S. Voringer S, et al. Among authors: muehlich s. Oncogene. 2020 Mar;39(11):2328-2344. doi: 10.1038/s41388-019-1140-8. Epub 2019 Dec 16. Oncogene. 2020. PMID: 31844251
Tetraspanin 5 (TSPAN5), a Novel Gatekeeper of the Tumor Suppressor DLC1 and Myocardin-Related Transcription Factors (MRTFs), Controls HCC Growth and Senescence.
Schreyer L, Mittermeier C, Franz MJ, Meier MA, Martin DE, Maier KC, Huebner K, Schneider-Stock R, Singer S, Holzer K, Fischer D, Ribback S, Liebl B, Gudermann T, Aigner A, Muehlich S. Schreyer L, et al. Among authors: muehlich s. Cancers (Basel). 2021 Oct 26;13(21):5373. doi: 10.3390/cancers13215373. Cancers (Basel). 2021. PMID: 34771537 Free PMC article.
LPA receptor 1 (LPAR1) is a novel interaction partner of Filamin A that promotes Filamin A phosphorylation, MRTF-A transcriptional activity and oncogene-induced senescence.
Konopa A, Meier MA, Franz MJ, Bernardinelli E, Voegele AL, Atreya R, Ribback S, Roessler S, Aigner A, Singer K, Singer S, Sarikas A, Muehlich S. Konopa A, et al. Among authors: muehlich s. Oncogenesis. 2022 Dec 28;11(1):69. doi: 10.1038/s41389-022-00445-z. Oncogenesis. 2022. PMID: 36577757 Free PMC article.
The novel MKL target gene myoferlin modulates expansion and senescence of hepatocellular carcinoma.
Hermanns C, Hampl V, Holzer K, Aigner A, Penkava J, Frank N, Martin DE, Maier KC, Waldburger N, Roessler S, Goppelt-Struebe M, Akrap I, Thavamani A, Singer S, Nordheim A, Gudermann T, Muehlich S. Hermanns C, et al. Among authors: muehlich s. Oncogene. 2017 Jun 15;36(24):3464-3476. doi: 10.1038/onc.2016.496. Epub 2017 Jan 23. Oncogene. 2017. PMID: 28114277
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