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Structure-specific amyloid precipitation in biofluids.
Rodrigues M, Bhattacharjee P, Brinkmalm A, Do DT, Pearson CM, De S, Ponjavic A, Varela JA, Kulenkampff K, Baudrexel I, Emin D, Ruggeri FS, Lee JE, Carr AR, Knowles TPJ, Zetterberg H, Snaddon TN, Gandhi S, Lee SF, Klenerman D. Rodrigues M, et al. Among authors: lee je, lee sf. Nat Chem. 2022 Sep;14(9):1045-1053. doi: 10.1038/s41557-022-00976-3. Epub 2022 Jul 7. Nat Chem. 2022. PMID: 35798951 Free article.
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids.
Horrocks MH, Lee SF, Gandhi S, Magdalinou NK, Chen SW, Devine MJ, Tosatto L, Kjaergaard M, Beckwith JS, Zetterberg H, Iljina M, Cremades N, Dobson CM, Wood NW, Klenerman D. Horrocks MH, et al. Among authors: lee sf. ACS Chem Neurosci. 2016 Mar 16;7(3):399-406. doi: 10.1021/acschemneuro.5b00324. Epub 2016 Feb 4. ACS Chem Neurosci. 2016. PMID: 26800462 Free PMC article.
Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping.
Bongiovanni MN, Godet J, Horrocks MH, Tosatto L, Carr AR, Wirthensohn DC, Ranasinghe RT, Lee JE, Ponjavic A, Fritz JV, Dobson CM, Klenerman D, Lee SF. Bongiovanni MN, et al. Among authors: lee je, lee sf. Nat Commun. 2016 Dec 8;7:13544. doi: 10.1038/ncomms13544. Nat Commun. 2016. PMID: 27929085 Free PMC article.
3D structures of individual mammalian genomes studied by single-cell Hi-C.
Stevens TJ, Lando D, Basu S, Atkinson LP, Cao Y, Lee SF, Leeb M, Wohlfahrt KJ, Boucher W, O'Shaughnessy-Kirwan A, Cramard J, Faure AJ, Ralser M, Blanco E, Morey L, Sansó M, Palayret MGS, Lehner B, Di Croce L, Wutz A, Hendrich B, Klenerman D, Laue ED. Stevens TJ, et al. Among authors: lee sf. Nature. 2017 Apr 6;544(7648):59-64. doi: 10.1038/nature21429. Epub 2017 Mar 13. Nature. 2017. PMID: 28289288 Free PMC article.
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.
Iljina M, Hong L, Horrocks MH, Ludtmann MH, Choi ML, Hughes CD, Ruggeri FS, Guilliams T, Buell AK, Lee JE, Gandhi S, Lee SF, Bryant CE, Vendruscolo M, Knowles TPJ, Dobson CM, De Genst E, Klenerman D. Iljina M, et al. Among authors: lee je, lee sf. BMC Biol. 2017 Jul 3;15(1):57. doi: 10.1186/s12915-017-0390-6. BMC Biol. 2017. PMID: 28673288 Free PMC article.
Optical Structural Analysis of Individual α-Synuclein Oligomers.
Varela JA, Rodrigues M, De S, Flagmeier P, Gandhi S, Dobson CM, Klenerman D, Lee SF. Varela JA, et al. Among authors: lee sf. Angew Chem Int Ed Engl. 2018 Apr 23;57(18):4886-4890. doi: 10.1002/anie.201710779. Epub 2018 Mar 23. Angew Chem Int Ed Engl. 2018. PMID: 29342318 Free PMC article.
544 results