Knowles TPJ - Search Results

1

Structure-specific amyloid precipitation in biofluids.

Rodrigues M, Bhattacharjee P, Brinkmalm A, Do DT, Pearson CM, De S, Ponjavic A, Varela JA, Kulenkampff K, Baudrexel I, Emin D, Ruggeri FS, Lee JE, Carr AR, Knowles TPJ, Zetterberg H, Snaddon TN, Gandhi S, Lee SF, Klenerman D. Rodrigues M, et al. Among authors: knowles tpj. Nat Chem. 2022 Sep;14(9):1045-1053. doi: 10.1038/s41557-022-00976-3. Epub 2022 Jul 7. Nat Chem. 2022. PMID: 35798951 Free article.

2

Single-molecule measurements of transient biomolecular complexes through microfluidic dilution.

Horrocks MH, Rajah L, Jönsson P, Kjaergaard M, Vendruscolo M, Knowles TP, Klenerman D. Horrocks MH, et al. Anal Chem. 2013 Jul 16;85(14):6855-9. doi: 10.1021/ac4010875. Epub 2013 Jun 27. Anal Chem. 2013. PMID: 23782428 Free PMC article.

3

Crucial role of nonspecific interactions in amyloid nucleation.

Šarić A, Chebaro YC, Knowles TP, Frenkel D. Šarić A, et al. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17869-74. doi: 10.1073/pnas.1410159111. Epub 2014 Dec 1. Proc Natl Acad Sci U S A. 2014. PMID: 25453085 Free PMC article.

4

On the lag phase in amyloid fibril formation.

Arosio P, Knowles TP, Linse S. Arosio P, et al. Phys Chem Chem Phys. 2015 Mar 28;17(12):7606-18. doi: 10.1039/c4cp05563b. Phys Chem Chem Phys. 2015. PMID: 25719972 Free PMC article. Review.

5

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers.

Shammas SL, Garcia GA, Kumar S, Kjaergaard M, Horrocks MH, Shivji N, Mandelkow E, Knowles TP, Mandelkow E, Klenerman D. Shammas SL, et al. Nat Commun. 2015 Apr 30;6:7025. doi: 10.1038/ncomms8025. Nat Commun. 2015. PMID: 25926130 Free PMC article.

6

Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers.

Horrocks MH, Tosatto L, Dear AJ, Garcia GA, Iljina M, Cremades N, Dalla Serra M, Knowles TP, Dobson CM, Klenerman D. Horrocks MH, et al. Anal Chem. 2015 Sep 1;87(17):8818-26. doi: 10.1021/acs.analchem.5b01811. Epub 2015 Aug 14. Anal Chem. 2015. PMID: 26258431

7

Molecular mechanisms of protein aggregation from global fitting of kinetic models.

Meisl G, Kirkegaard JB, Arosio P, Michaels TC, Vendruscolo M, Dobson CM, Linse S, Knowles TP. Meisl G, et al. Nat Protoc. 2016 Feb;11(2):252-72. doi: 10.1038/nprot.2016.010. Epub 2016 Jan 7. Nat Protoc. 2016. PMID: 26741409

8

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.

Iljina M, Garcia GA, Horrocks MH, Tosatto L, Choi ML, Ganzinger KA, Abramov AY, Gandhi S, Wood NW, Cremades N, Dobson CM, Knowles TP, Klenerman D. Iljina M, et al. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1206-15. doi: 10.1073/pnas.1524128113. Epub 2016 Feb 16. Proc Natl Acad Sci U S A. 2016. PMID: 26884195 Free PMC article.

9

Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms.

Iljina M, Garcia GA, Dear AJ, Flint J, Narayan P, Michaels TC, Dobson CM, Frenkel D, Knowles TP, Klenerman D. Iljina M, et al. Sci Rep. 2016 Jun 27;6:28658. doi: 10.1038/srep28658. Sci Rep. 2016. PMID: 27346247 Free PMC article.

10

Ultrasensitive Measurement of Ca²⁺ Influx into Lipid Vesicles Induced by Protein Aggregates.

Flagmeier P, De S, Wirthensohn DC, Lee SF, Vincke C, Muyldermans S, Knowles TPJ, Gandhi S, Dobson CM, Klenerman D. Flagmeier P, et al. Among authors: knowles tpj. Angew Chem Int Ed Engl. 2017 Jun 26;56(27):7750-7754. doi: 10.1002/anie.201700966. Epub 2017 May 5. Angew Chem Int Ed Engl. 2017. PMID: 28474754 Free PMC article.

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