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Mapping of the sGC Stimulator BAY 41-2272 Binding Site on H-NOX Domain and Its Regulation by the Redox State of the Heme.
Front Cell Dev Biol. 2022 Jun 17;10:925457. doi: 10.3389/fcell.2022.925457. eCollection 2022.
Front Cell Dev Biol. 2022.
PMID: 35784456
Free PMC article.
Replacement of heme by soluble guanylate cyclase (sGC) activators abolishes heme-nitric oxide/oxygen (H-NOX) domain structural plasticity.
Argyriou AI, Makrynitsa GI, Dalkas G, Georgopoulou DA, Salagiannis K, Vazoura V, Papapetropoulos A, Topouzis S, Spyroulias GA.
Argyriou AI, et al. Among authors: salagiannis k.
Curr Res Struct Biol. 2021 Nov 18;3:324-336. doi: 10.1016/j.crstbi.2021.11.003. eCollection 2021.
Curr Res Struct Biol. 2021.
PMID: 34901882
Free PMC article.
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Identification of new multi-substituted 1H-pyrazolo[3,4-c]pyridin-7(6H)-ones as soluble guanylyl cyclase (sGC) stimulators with vasoprotective and anti-inflammatory activities.
Kintos DP, Salagiannis K, Sgouros A, Nikolaropoulos SS, Topouzis S, Fousteris MA.
Kintos DP, et al. Among authors: salagiannis k.
Bioorg Chem. 2024 Mar;144:107170. doi: 10.1016/j.bioorg.2024.107170. Epub 2024 Feb 2.
Bioorg Chem. 2024.
PMID: 38335755
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Design, synthesis and biological evaluation of new 3,4-dihydroquinoxalin-2(1H)-one derivatives as soluble guanylyl cyclase (sGC) activators.
Kintos DP, Salagiannis K, Vazoura V, Wittrien T, Papakyriakou A, Nikolaropoulos SS, Behrends S, Topouzis S, Fousteris MA.
Kintos DP, et al. Among authors: salagiannis k.
Heliyon. 2022 Nov 6;8(11):e11438. doi: 10.1016/j.heliyon.2022.e11438. eCollection 2022 Nov.
Heliyon. 2022.
PMID: 36387474
Free PMC article.
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