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Large scale clinical trials: lessons from the COVID-19 pandemic.
Horsley AR, Pearmain L, Knight S, Schindler N, Wang R, Bennett M, Robey RC, Davies JC, Djukanović R, Heaney LG, Hussell T, Marciniak SJ, McGarvey LP, Porter J, Wilkinson T, Brightling C, Ho LP. Horsley AR, et al. Among authors: wilkinson t. BMJ Open Respir Res. 2022 Jun;9(1):e001226. doi: 10.1136/bmjresp-2022-001226. BMJ Open Respir Res. 2022. PMID: 35701071 Free PMC article.
Viral infection of human lung macrophages increases PDL1 expression via IFNβ.
Staples KJ, Nicholas B, McKendry RT, Spalluto CM, Wallington JC, Bragg CW, Robinson EC, Martin K, Djukanović R, Wilkinson TM. Staples KJ, et al. Among authors: wilkinson tm. PLoS One. 2015 Mar 16;10(3):e0121527. doi: 10.1371/journal.pone.0121527. eCollection 2015. PLoS One. 2015. PMID: 25775126 Free PMC article.
Dexamethasone in Hospitalized Patients with Covid-19.
RECOVERY Collaborative Group; Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, Staplin N, Brightling C, Ustianowski A, Elmahi E, Prudon B, Green C, Felton T, Chadwick D, Rege K, Fegan C, Chappell LC, Faust SN, Jaki T, Jeffery K, Montgomery A, Rowan K, Juszczak E, Baillie JK, Haynes R, Landray MJ. RECOVERY Collaborative Group, et al. N Engl J Med. 2021 Feb 25;384(8):693-704. doi: 10.1056/NEJMoa2021436. Epub 2020 Jul 17. N Engl J Med. 2021. PMID: 32678530 Free PMC article. Clinical Trial.
ACCORD: A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalised Patients: A structured summary of a study protocol for a randomised controlled trial.
Wilkinson T, Dixon R, Page C, Carroll M, Griffiths G, Ho LP, De Soyza A, Felton T, Lewis KE, Phekoo K, Chalmers JD, Gordon A, McGarvey L, Doherty J, Read RC, Shankar-Hari M, Martinez-Alier N, O'Kelly M, Duncan G, Walles R, Sykes J, Summers C, Singh D; ACCORD Collaborators. Wilkinson T, et al. Trials. 2020 Jul 31;21(1):691. doi: 10.1186/s13063-020-04584-9. Trials. 2020. PMID: 32736596 Free PMC article.
Inflammatory phenotyping predicts clinical outcome in COVID-19.
Burke H, Freeman A, Cellura DC, Stuart BL, Brendish NJ, Poole S, Borca F, Phan HTT, Sheard N, Williams S, Spalluto CM, Staples KJ, Clark TW, Wilkinson TMA; REACT COVID investigators. Burke H, et al. Among authors: wilkinson tma. Respir Res. 2020 Sep 22;21(1):245. doi: 10.1186/s12931-020-01511-z. Respir Res. 2020. PMID: 32962703 Free PMC article.
Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19.
RECOVERY Collaborative Group; Horby P, Mafham M, Linsell L, Bell JL, Staplin N, Emberson JR, Wiselka M, Ustianowski A, Elmahi E, Prudon B, Whitehouse T, Felton T, Williams J, Faccenda J, Underwood J, Baillie JK, Chappell LC, Faust SN, Jaki T, Jeffery K, Lim WS, Montgomery A, Rowan K, Tarning J, Watson JA, White NJ, Juszczak E, Haynes R, Landray MJ. RECOVERY Collaborative Group, et al. N Engl J Med. 2020 Nov 19;383(21):2030-2040. doi: 10.1056/NEJMoa2022926. Epub 2020 Oct 8. N Engl J Med. 2020. PMID: 33031652 Free PMC article. Clinical Trial.
Dysregulation of COVID-19 related gene expression in the COPD lung.
Watson A, Öberg L, Angermann B, Spalluto CM, Hühn M, Burke H, Cellura D, Freeman A, Muthas D, Etal D, Belfield G, Karlsson F, Nordström K, Ostridge K, Staples KJ, Wilkinson T; MICA II Studygroup. Watson A, et al. Among authors: wilkinson t. Respir Res. 2021 May 29;22(1):164. doi: 10.1186/s12931-021-01755-3. Respir Res. 2021. PMID: 34051791 Free PMC article.
Early-phase clinical trials in a pandemic: learning from the response to COVID-19.
Horsley A, Brightling C, Davies J, Djukanovic R, Heaney LG, Hussell T, Marciniak SJ, McGarvey L, Porter JC, Wilkinson T, Ho LP; NIHR Respiratory Translational Research Collaboration network. Horsley A, et al. Among authors: wilkinson t. Lancet Respir Med. 2022 Jul;10(7):625-627. doi: 10.1016/S2213-2600(22)00062-5. Epub 2022 Jun 13. Lancet Respir Med. 2022. PMID: 35709826 Free PMC article. No abstract available.
A randomised phase 2a study to investigate the effects of blocking interleukin-33 with tozorakimab in patients hospitalised with COVID-19: ACCORD-2.
Wilkinson T, De Soyza A, Carroll M, Chalmers JD, Crooks MG, Griffiths G, Shankar-Hari M, Ho LP, Horsley A, Kell C, Lara B, Mishra B, Moate R, Page C, Pandya H, Raw J, Reid F, Saralaya D, Scott IC, Siddiqui S, Ustianowski A, van Zuydam N, Woodcock A, Singh D. Wilkinson T, et al. ERJ Open Res. 2023 Oct 2;9(5):00249-2023. doi: 10.1183/23120541.00249-2023. eCollection 2023 Sep. ERJ Open Res. 2023. PMID: 37868151 Free PMC article.
1,178 results