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Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain.
Kinnebrew M, Woolley RE, Ansell TB, Byrne EFX, Frigui S, Luchetti G, Sircar R, Nachtergaele S, Mydock-McGrane L, Krishnan K, Newstead S, Sansom MSP, Covey DF, Siebold C, Rohatgi R. Kinnebrew M, et al. Among authors: rohatgi r. Sci Adv. 2022 Jun 3;8(22):eabm5563. doi: 10.1126/sciadv.abm5563. Epub 2022 Jun 3. Sci Adv. 2022. PMID: 35658032 Free PMC article.
Oxysterols are allosteric activators of the oncoprotein Smoothened.
Nachtergaele S, Mydock LK, Krishnan K, Rammohan J, Schlesinger PH, Covey DF, Rohatgi R. Nachtergaele S, et al. Among authors: rohatgi r. Nat Chem Biol. 2012 Jan 8;8(2):211-20. doi: 10.1038/nchembio.765. Nat Chem Biol. 2012. PMID: 22231273 Free PMC article.
A novel osteogenic oxysterol compound for therapeutic development to promote bone growth: activation of hedgehog signaling and osteogenesis through smoothened binding.
Montgomery SR, Nargizyan T, Meliton V, Nachtergaele S, Rohatgi R, Stappenbeck F, Jung ME, Johnson JS, Aghdasi B, Tian H, Weintraub G, Inoue H, Atti E, Tetradis S, Pereira RC, Hokugo A, Alobaidaan R, Tan Y, Hahn TJ, Wang JC, Parhami F. Montgomery SR, et al. Among authors: rohatgi r. J Bone Miner Res. 2014 Aug;29(8):1872-85. doi: 10.1002/jbmr.2213. J Bone Miner Res. 2014. PMID: 24591126 Free PMC article.
Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling.
Marada S, Navarro G, Truong A, Stewart DP, Arensdorf AM, Nachtergaele S, Angelats E, Opferman JT, Rohatgi R, McCormick PJ, Ogden SK. Marada S, et al. Among authors: rohatgi r. PLoS Genet. 2015 Aug 20;11(8):e1005473. doi: 10.1371/journal.pgen.1005473. eCollection 2015 Aug. PLoS Genet. 2015. PMID: 26291458 Free PMC article.
Structural basis of Smoothened regulation by its extracellular domains.
Byrne EFX, Sircar R, Miller PS, Hedger G, Luchetti G, Nachtergaele S, Tully MD, Mydock-McGrane L, Covey DF, Rambo RP, Sansom MSP, Newstead S, Rohatgi R, Siebold C. Byrne EFX, et al. Among authors: rohatgi r. Nature. 2016 Jul 28;535(7613):517-522. doi: 10.1038/nature18934. Epub 2016 Jul 20. Nature. 2016. PMID: 27437577 Free PMC article.
164 results