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Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain.
Kinnebrew M, Woolley RE, Ansell TB, Byrne EFX, Frigui S, Luchetti G, Sircar R, Nachtergaele S, Mydock-McGrane L, Krishnan K, Newstead S, Sansom MSP, Covey DF, Siebold C, Rohatgi R. Kinnebrew M, et al. Among authors: mydock mcgrane l. Sci Adv. 2022 Jun 3;8(22):eabm5563. doi: 10.1126/sciadv.abm5563. Epub 2022 Jun 3. Sci Adv. 2022. PMID: 35658032 Free PMC article.
Structural basis of Smoothened regulation by its extracellular domains.
Byrne EFX, Sircar R, Miller PS, Hedger G, Luchetti G, Nachtergaele S, Tully MD, Mydock-McGrane L, Covey DF, Rambo RP, Sansom MSP, Newstead S, Rohatgi R, Siebold C. Byrne EFX, et al. Among authors: mydock mcgrane l. Nature. 2016 Jul 28;535(7613):517-522. doi: 10.1038/nature18934. Epub 2016 Jul 20. Nature. 2016. PMID: 27437577 Free PMC article.
Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel.
Budelier MM, Cheng WWL, Chen ZW, Bracamontes JR, Sugasawa Y, Krishnan K, Mydock-McGrane L, Covey DF, Evers AS. Budelier MM, et al. Among authors: mydock mcgrane l. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Feb;1864(2):128-136. doi: 10.1016/j.bbalip.2018.11.005. Epub 2018 Nov 22. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 30471426 Free PMC article.
Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1.
Budelier MM, Cheng WWL, Bergdoll L, Chen ZW, Janetka JW, Abramson J, Krishnan K, Mydock-McGrane L, Covey DF, Whitelegge JP, Evers AS. Budelier MM, et al. Among authors: mydock mcgrane l. J Biol Chem. 2017 Jun 2;292(22):9294-9304. doi: 10.1074/jbc.M116.773069. Epub 2017 Apr 10. J Biol Chem. 2017. PMID: 28396346 Free PMC article.
Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.
Castellano BM, Thelen AM, Moldavski O, Feltes M, van der Welle RE, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey DF, Nomura DK, Ory DS, Zoncu R. Castellano BM, et al. Among authors: mydock mcgrane l. Science. 2017 Mar 24;355(6331):1306-1311. doi: 10.1126/science.aag1417. Science. 2017. PMID: 28336668 Free PMC article.
17 results