Covey DF - Search Results

1

Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain.

Kinnebrew M, Woolley RE, Ansell TB, Byrne EFX, Frigui S, Luchetti G, Sircar R, Nachtergaele S, Mydock-McGrane L, Krishnan K, Newstead S, Sansom MSP, Covey DF, Siebold C, Rohatgi R. Kinnebrew M, et al. Among authors: covey df. Sci Adv. 2022 Jun 3;8(22):eabm5563. doi: 10.1126/sciadv.abm5563. Epub 2022 Jun 3. Sci Adv. 2022. PMID: 35658032 Free PMC article.

2

Comparison of effects of U18666A and enantiomeric U18666A on sterol synthesis and induction of apoptosis.

Cenedella RJ, Sexton PS, Krishnan K, Covey DF. Cenedella RJ, et al. Among authors: covey df. Lipids. 2005 Jun;40(6):635-40. doi: 10.1007/s11745-005-1426-9. Lipids. 2005. PMID: 16149744

3

GABAergic neurosteroids mediate the effects of ethanol on long-term potentiation in rat hippocampal slices.

Izumi Y, Murayama K, Tokuda K, Krishnan K, Covey DF, Zorumski CF. Izumi Y, et al. Among authors: covey df. Eur J Neurosci. 2007 Oct;26(7):1881-8. doi: 10.1111/j.1460-9568.2007.05809.x. Epub 2007 Sep 20. Eur J Neurosci. 2007. PMID: 17883414

4

Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions.

Gale SE, Westover EJ, Dudley N, Krishnan K, Merlin S, Scherrer DE, Han X, Zhai X, Brockman HL, Brown RE, Covey DF, Schaffer JE, Schlesinger P, Ory DS. Gale SE, et al. Among authors: covey df. J Biol Chem. 2009 Jan 16;284(3):1755-64. doi: 10.1074/jbc.M807210200. Epub 2008 Nov 6. J Biol Chem. 2009. PMID: 18996837 Free PMC article.

5

Synthesis of 19-Trideuterated ent-Testosterone and the GABA(A) Receptor Potentiators ent-Androsterone and ent-Etiocholanolone.

Komarapuri S, Krishnan K, Covey DF. Komarapuri S, et al. Among authors: covey df. J Labelled Comp Radiopharm. 2008 Nov;51(14):430-434. doi: 10.1002/jlcr.1558. J Labelled Comp Radiopharm. 2008. PMID: 19122784 Free PMC article.

6

The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction.

Chisari M, Eisenman LN, Krishnan K, Bandyopadhyaya AK, Wang C, Taylor A, Benz A, Covey DF, Zorumski CF, Mennerick S. Chisari M, et al. Among authors: covey df. J Neurophysiol. 2009 Aug;102(2):1254-64. doi: 10.1152/jn.00346.2009. Epub 2009 Jun 24. J Neurophysiol. 2009. PMID: 19553485 Free PMC article.

7

Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic activity.

Stastna E, Krishnan K, Manion BD, Taylor A, Rath NP, Chen ZW, Evers AS, Zorumski CF, Mennerick S, Covey DF. Stastna E, et al. Among authors: covey df. J Med Chem. 2011 Jun 9;54(11):3926-34. doi: 10.1021/jm2002487. Epub 2011 May 6. J Med Chem. 2011. PMID: 21504158 Free PMC article.

8

Glucuronidation of the steroid enantiomers ent-17β-estradiol, ent-androsterone and ent-etiocholanolone by the human UDP-glucuronosyltransferases.

Sneitz N, Krishnan K, Covey DF, Finel M. Sneitz N, et al. Among authors: covey df. J Steroid Biochem Mol Biol. 2011 Nov;127(3-5):282-8. doi: 10.1016/j.jsbmb.2011.08.008. Epub 2011 Aug 27. J Steroid Biochem Mol Biol. 2011. PMID: 21899827 Free PMC article.

9

Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on γ-aminobutyric acid type A receptors.

Krishnan K, Manion BD, Taylor A, Bracamontes J, Steinbach JH, Reichert DE, Evers AS, Zorumski CF, Mennerick S, Covey DF. Krishnan K, et al. Among authors: covey df. J Med Chem. 2012 Feb 9;55(3):1334-45. doi: 10.1021/jm2014925. Epub 2012 Jan 18. J Med Chem. 2012. PMID: 22191644 Free PMC article.

10

Oxysterols are allosteric activators of the oncoprotein Smoothened.

Nachtergaele S, Mydock LK, Krishnan K, Rammohan J, Schlesinger PH, Covey DF, Rohatgi R. Nachtergaele S, et al. Among authors: covey df. Nat Chem Biol. 2012 Jan 8;8(2):211-20. doi: 10.1038/nchembio.765. Nat Chem Biol. 2012. PMID: 22231273 Free PMC article.

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