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Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition.
Hinchliffe P, Tooke CL, Bethel CR, Wang B, Arthur C, Heesom KJ, Shapiro S, Schlatzer DM, Papp-Wallace KM, Bonomo RA, Spencer J. Hinchliffe P, et al. Among authors: heesom kj. mBio. 2022 Jun 28;13(3):e0179321. doi: 10.1128/mbio.01793-21. Epub 2022 May 25. mBio. 2022. PMID: 35612361 Free PMC article.
Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors.
Clennell B, Steward TGJ, Hanman K, Needham T, Benachour J, Jepson M, Elley M, Halford N, Heesom K, Shin E, Molnár E, Drinkwater BW, Whitcomb DJ. Clennell B, et al. Brain Stimul. 2023 Mar-Apr;16(2):540-552. doi: 10.1016/j.brs.2023.01.1674. Epub 2023 Jan 31. Brain Stimul. 2023. PMID: 36731773 Free article.
Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome.
Healy MD, McNally KE, Butkovič R, Chilton M, Kato K, Sacharz J, McConville C, Moody ERR, Shaw S, Planelles-Herrero VJ, Yadav SKN, Ross J, Borucu U, Palmer CS, Chen KE, Croll TI, Hall RJ, Caruana NJ, Ghai R, Nguyen THD, Heesom KJ, Saitoh S, Berger I, Schaffitzel C, Williams TA, Stroud DA, Derivery E, Collins BM, Cullen PJ. Healy MD, et al. Among authors: heesom kj. Cell. 2023 May 11;186(10):2219-2237.e29. doi: 10.1016/j.cell.2023.04.003. Cell. 2023. PMID: 37172566 Free PMC article.
Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates.
Calvopiña K, Hinchliffe P, Brem J, Heesom KJ, Johnson S, Cain R, Lohans CT, Fishwick CWG, Schofield CJ, Spencer J, Avison MB. Calvopiña K, et al. Among authors: heesom kj. Mol Microbiol. 2017 Nov;106(3):492-504. doi: 10.1111/mmi.13831. Epub 2017 Sep 21. Mol Microbiol. 2017. PMID: 28876489 Free article.
153 results