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Laminin isoforms containing the gamma3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma1 and gamma2 chains.
Ido H, Ito S, Taniguchi Y, Hayashi M, Sato-Nishiuchi R, Sanzen N, Hayashi Y, Futaki S, Sekiguchi K. Ido H, et al. Among authors: sekiguchi k. J Biol Chem. 2008 Oct 17;283(42):28149-57. doi: 10.1074/jbc.M803553200. Epub 2008 Aug 12. J Biol Chem. 2008. PMID: 18697739 Free PMC article.
Anti-laminin gamma-1 pemphigoid.
Dainichi T, Kurono S, Ohyama B, Ishii N, Sanzen N, Hayashi M, Shimono C, Taniguchi Y, Koga H, Karashima T, Yasumoto S, Zillikens D, Sekiguchi K, Hashimoto T. Dainichi T, et al. Among authors: sekiguchi k. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2800-5. doi: 10.1073/pnas.0809230106. Epub 2009 Feb 5. Proc Natl Acad Sci U S A. 2009. PMID: 19196964 Free PMC article.
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