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Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation.
van der Stel W, Yang H, Vrijenhoek NG, Schimming JP, Callegaro G, Carta G, Darici S, Delp J, Forsby A, White A, le Dévédec S, Leist M, Jennings P, Beltman JB, van de Water B, Danen EHJ. van der Stel W, et al. Among authors: yang h. Arch Toxicol. 2022 Jan;96(1):259-285. doi: 10.1007/s00204-021-03160-7. Epub 2021 Oct 13. Arch Toxicol. 2022. PMID: 34642769 Free PMC article.
Model-based translation of DNA damage signaling dynamics across cell types.
Heldring MM, Wijaya LS, Niemeijer M, Yang H, Lakhal T, Le Dévédec SE, van de Water B, Beltman JB. Heldring MM, et al. Among authors: yang h. PLoS Comput Biol. 2022 Jul 8;18(7):e1010264. doi: 10.1371/journal.pcbi.1010264. eCollection 2022 Jul. PLoS Comput Biol. 2022. PMID: 35802572 Free PMC article.
Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury.
Wijaya LS, Trairatphisan P, Gabor A, Niemeijer M, Keet J, Alcalà Morera A, Snijders KE, Wink S, Yang H, Schildknecht S, Stevens JL, Bouwman P, Kamp H, Hengstler J, Beltman J, Leist M, Le Dévédec S, Saez-Rodriguez J, van de Water B. Wijaya LS, et al. Among authors: yang h. Biochem Pharmacol. 2021 Aug;190:114591. doi: 10.1016/j.bcp.2021.114591. Epub 2021 May 4. Biochem Pharmacol. 2021. PMID: 33957093 Free article.
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