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Brain-specific deletion of GIT1 impairs cognition and alters phosphorylation of synaptic protein networks implicated in schizophrenia susceptibility.
Fass DM, Lewis MC, Ahmad R, Szucs MJ, Zhang Q, Fleishman M, Wang D, Kim MJ, Biag J, Carr SA, Scolnick EM, Premont RT, Haggarty SJ. Fass DM, et al. Among authors: premont rt. Mol Psychiatry. 2022 Aug;27(8):3272-3285. doi: 10.1038/s41380-022-01557-z. Epub 2022 May 3. Mol Psychiatry. 2022. PMID: 35505090 Free PMC article.
Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity.
Kim MJ, Biag J, Fass DM, Lewis MC, Zhang Q, Fleishman M, Gangwar SP, Machius M, Fromer M, Purcell SM, McCarroll SA, Rudenko G, Premont RT, Scolnick EM, Haggarty SJ. Kim MJ, et al. Among authors: premont rt. Mol Psychiatry. 2017 Mar;22(3):417-429. doi: 10.1038/mp.2016.98. Epub 2016 Jul 26. Mol Psychiatry. 2017. PMID: 27457813 Free PMC article.
S-nitrosylation is required for β2AR desensitization and experimental asthma.
Fonseca FV, Raffay TM, Xiao K, McLaughlin PJ, Qian Z, Grimmett ZW, Adachi N, Wang B, Hausladen A, Cobb BA, Zhang R, Hess DT, Gaston B, Lambert NA, Reynolds JD, Premont RT, Stamler JS. Fonseca FV, et al. Among authors: premont rt. Mol Cell. 2022 Aug 18;82(16):3089-3102.e7. doi: 10.1016/j.molcel.2022.06.033. Epub 2022 Aug 4. Mol Cell. 2022. PMID: 35931084 Free PMC article.
β-Arrestin2 is a critical component of the GPCR-eNOS signalosome.
Liu S, Luttrell LM, Premont RT, Rockey DC. Liu S, et al. Among authors: premont rt. Proc Natl Acad Sci U S A. 2020 May 26;117(21):11483-11492. doi: 10.1073/pnas.1922608117. Epub 2020 May 13. Proc Natl Acad Sci U S A. 2020. PMID: 32404425 Free PMC article.
GIT1 regulates synaptic structural plasticity underlying learning.
Martyn AC, Toth K, Schmalzigaug R, Hedrick NG, Rodriguiz RM, Yasuda R, Wetsel WC, Premont RT. Martyn AC, et al. Among authors: premont rt. PLoS One. 2018 Mar 19;13(3):e0194350. doi: 10.1371/journal.pone.0194350. eCollection 2018. PLoS One. 2018. PMID: 29554125 Free PMC article.
167 results