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Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins.
Metab Eng. 2022 Jul;72:171-187. doi: 10.1016/j.ymben.2022.03.009. Epub 2022 Mar 14.
Metab Eng. 2022.
PMID: 35301123
Free PMC article.
Autophagy and intracellular product degradation genes identified by systems biology analysis reduce aggregation of bispecific antibody in CHO cells.
Barzadd MM, Lundqvist M, Harris C, Malm M, Volk AL, Thalén N, Chotteau V, Grassi L, Smith A, Abadi ML, Lambiase G, Gibson S, Hatton D, Rockberg J.
Barzadd MM, et al.
N Biotechnol. 2022 May 25;68:68-76. doi: 10.1016/j.nbt.2022.01.010. Epub 2022 Feb 2.
N Biotechnol. 2022.
PMID: 35123066
Free article.
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Tuning of CHO secretional machinery improve activity of secreted therapeutic sulfatase 150-fold.
Thalén NB, Barzadd MM, Lundqvist M, Rodhe J, Andersson M, Bidkhori G, Possner D, Su C, Nilsson J, Eisenhut P, Malm M, Karlsson A, Vestin J, Forsberg J, Nordling E, Mardinoglu A, Volk AL, Sandegren A, Rockberg J.
Thalén NB, et al. Among authors: barzadd mm.
Metab Eng. 2024 Jan;81:157-166. doi: 10.1016/j.ymben.2023.12.003. Epub 2023 Dec 9.
Metab Eng. 2024.
PMID: 38081506
Free article.
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