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Protein C or Protein S deficiency associates with paradoxically impaired platelet-dependent thrombus and fibrin formation under flow.
Brouns SLN, Tullemans BME, Bulato C, Perrella G, Campello E, Spiezia L, van Geffen JP, Kuijpers MJE, van Oerle R, Spronk HMH, van der Meijden PEJ, Simioni P, Heemskerk JWM. Brouns SLN, et al. Among authors: van geffen jp. Res Pract Thromb Haemost. 2022 Mar 7;6(2):e12678. doi: 10.1002/rth2.12678. eCollection 2022 Feb. Res Pract Thromb Haemost. 2022. PMID: 35284776 Free PMC article.
Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation.
Brouns SLN, van Geffen JP, Campello E, Swieringa F, Spiezia L, van Oerle R, Provenzale I, Verdoold R, Farndale RW, Clemetson KJ, Spronk HMH, van der Meijden PEJ, Cavill R, Kuijpers MJE, Castoldi E, Simioni P, Heemskerk JWM. Brouns SLN, et al. Among authors: van geffen jp. Sci Rep. 2020 Jul 17;10(1):11910. doi: 10.1038/s41598-020-68438-9. Sci Rep. 2020. PMID: 32680988 Free PMC article.
Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase β, and Not Via CD40 and IκB Kinase α.
Kuijpers MJ, Mattheij NJ, Cipolla L, van Geffen JP, Lawrence T, Donners MM, Boon L, Lievens D, Torti M, Noels H, Gerdes N, Cosemans JM, Lutgens E, Heemskerk JW. Kuijpers MJ, et al. Among authors: van geffen jp. Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1374-81. doi: 10.1161/ATVBAHA.114.305127. Epub 2015 Apr 23. Arterioscler Thromb Vasc Biol. 2015. PMID: 25908768
High-throughput elucidation of thrombus formation reveals sources of platelet function variability.
van Geffen JP, Brouns SLN, Batista J, McKinney H, Kempster C, Nagy M, Sivapalaratnam S, Baaten CCFMJ, Bourry N, Frontini M, Jurk K, Krause M, Pillitteri D, Swieringa F, Verdoold R, Cavill R, Kuijpers MJE, Ouwehand WH, Downes K, Heemskerk JWM. van Geffen JP, et al. Haematologica. 2019 Jun;104(6):1256-1267. doi: 10.3324/haematol.2018.198853. Epub 2018 Dec 13. Haematologica. 2019. PMID: 30545925 Free PMC article.
21 results