Flaherty DP - Search Results

1

Optimization of a Pyrimidinone Series for Selective Inhibition of Ca²⁺/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain.

Scott JA, Soto-Velasquez M, Hayes MP, LaVigne JE, Miller HR, Kaur J, Ejendal KFK, Watts VJ, Flaherty DP. Scott JA, et al. Among authors: flaherty dp. J Med Chem. 2022 Mar 24;65(6):4667-4686. doi: 10.1021/acs.jmedchem.1c01759. Epub 2022 Mar 10. J Med Chem. 2022. PMID: 35271288 Free PMC article.

2

Optimization of potent and selective quinazolinediones: inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activity.

Matharu DS, Flaherty DP, Simpson DS, Schroeder CE, Chung D, Yan D, Noah JW, Jonsson CB, White EL, Aubé J, Plemper RK, Severson WE, Golden JE. Matharu DS, et al. Among authors: flaherty dp. J Med Chem. 2014 Dec 26;57(24):10314-28. doi: 10.1021/jm500902x. Epub 2014 Dec 4. J Med Chem. 2014. PMID: 25399509 Free PMC article.

3

Optimization of a 1,3,4-oxadiazole series for inhibition of Ca²⁺/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain.

Kaur J, Soto-Velasquez M, Ding Z, Ghanbarpour A, Lill MA, van Rijn RM, Watts VJ, Flaherty DP. Kaur J, et al. Among authors: flaherty dp. Eur J Med Chem. 2019 Jan 15;162:568-585. doi: 10.1016/j.ejmech.2018.11.036. Epub 2018 Nov 16. Eur J Med Chem. 2019. PMID: 30472604 Free PMC article.

4

Optimization of Acetazolamide-Based Scaffold as Potent Inhibitors of Vancomycin-Resistant Enterococcus.

Kaur J, Cao X, Abutaleb NS, Elkashif A, Graboski AL, Krabill AD, AbdelKhalek AH, An W, Bhardwaj A, Seleem MN, Flaherty DP. Kaur J, et al. Among authors: flaherty dp. J Med Chem. 2020 Sep 10;63(17):9540-9562. doi: 10.1021/acs.jmedchem.0c00734. Epub 2020 Aug 11. J Med Chem. 2020. PMID: 32787141 Free PMC article.

5

Structure-Activity Relationship Studies of Acetazolamide-Based Carbonic Anhydrase Inhibitors with Activity against Neisseria gonorrhoeae.

Hewitt CS, Abutaleb NS, Elhassanny AEM, Nocentini A, Cao X, Amos DP, Youse MS, Holly KJ, Marapaka AK, An W, Kaur J, Krabill AD, Elkashif A, Elgammal Y, Graboski AL, Supuran CT, Seleem MN, Flaherty DP. Hewitt CS, et al. Among authors: flaherty dp. ACS Infect Dis. 2021 Jul 9;7(7):1969-1984. doi: 10.1021/acsinfecdis.1c00055. Epub 2021 Mar 25. ACS Infect Dis. 2021. PMID: 33765392 Free PMC article.

6

Inhibition studies of bacterial α-carbonic anhydrases with phenols.

Giovannuzzi S, Hewitt CS, Nocentini A, Capasso C, Costantino G, Flaherty DP, Supuran CT. Giovannuzzi S, et al. Among authors: flaherty dp. J Enzyme Inhib Med Chem. 2022 Dec;37(1):666-671. doi: 10.1080/14756366.2022.2038592. J Enzyme Inhib Med Chem. 2022. PMID: 35139743 Free PMC article.

7

High-content phenotypic screening identifies novel chemistries that disrupt mosquito activity and development.

Murgia MV, Sharan S, Kaur J, Austin W, Hagen L, Wu L, Chen L, Scott JA, Flaherty DP, Scharf ME, Watts VJ, Hill CA. Murgia MV, et al. Among authors: flaherty dp. Pestic Biochem Physiol. 2022 Mar;182:105037. doi: 10.1016/j.pestbp.2022.105037. Epub 2022 Jan 10. Pestic Biochem Physiol. 2022. PMID: 35249647 Free article.

8

Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype.

Dwyer TS, O'Brien JB, Ptak CP, LaVigne JE, Flaherty DP, Watts VJ, Roman DL. Dwyer TS, et al. Among authors: flaherty dp. Front Pharmacol. 2022 Sep 6;13:977742. doi: 10.3389/fphar.2022.977742. eCollection 2022. Front Pharmacol. 2022. PMID: 36147328 Free PMC article.

9

Structural Characterization of Thiadiazolesulfonamide Inhibitors Bound to Neisseria gonorrhoeae α-Carbonic Anhydrase.

Marapaka AK, Nocentini A, Youse MS, An W, Holly KJ, Das C, Yadav R, Seleem MN, Supuran CT, Flaherty DP. Marapaka AK, et al. Among authors: flaherty dp. ACS Med Chem Lett. 2022 Dec 6;14(1):103-109. doi: 10.1021/acsmedchemlett.2c00471. eCollection 2023 Jan 12. ACS Med Chem Lett. 2022. PMID: 36655133 Free PMC article.

10

Evaluation of 1,3,4-Thiadiazole Carbonic Anhydrase Inhibitors for Gut Decolonization of Vancomycin-Resistant Enterococci.

Abutaleb NS, Shrinidhi A, Bandara AB, Seleem MN, Flaherty DP. Abutaleb NS, et al. Among authors: flaherty dp. ACS Med Chem Lett. 2023 Mar 21;14(4):487-492. doi: 10.1021/acsmedchemlett.3c00032. eCollection 2023 Apr 13. ACS Med Chem Lett. 2023. PMID: 37077393 Free PMC article.

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