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Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease.
Codony S, Pont C, Griñán-Ferré C, Di Pede-Mattatelli A, Calvó-Tusell C, Feixas F, Osuna S, Jarné-Ferrer J, Naldi M, Bartolini M, Loza MI, Brea J, Pérez B, Bartra C, Sanfeliu C, Juárez-Jiménez J, Morisseau C, Hammock BD, Pallàs M, Vázquez S, Muñoz-Torrero D. Codony S, et al. Among authors: vazquez s. J Med Chem. 2022 Mar 24;65(6):4909-4925. doi: 10.1021/acs.jmedchem.1c02150. Epub 2022 Mar 10. J Med Chem. 2022. PMID: 35271276 Free PMC article.
Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs.
Camps P, Duque MD, Vázquez S, Naesens L, De Clercq E, Sureda FX, López-Querol M, Camins A, Pallàs M, Prathalingam SR, Kelly JM, Romero V, Ivorra D, Cortés D. Camps P, et al. Among authors: vazquez s. Bioorg Med Chem. 2008 Dec 1;16(23):9925-36. doi: 10.1016/j.bmc.2008.10.028. Epub 2008 Oct 17. Bioorg Med Chem. 2008. PMID: 18954995 Free PMC article.
3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.
Rey-Carrizo M, Torres E, Ma C, Barniol-Xicota M, Wang J, Wu Y, Naesens L, DeGrado WF, Lamb RA, Pinto LH, Vázquez S. Rey-Carrizo M, et al. Among authors: vazquez s. J Med Chem. 2013 Nov 27;56(22):9265-74. doi: 10.1021/jm401340p. Epub 2013 Nov 15. J Med Chem. 2013. PMID: 24237039 Free PMC article.
Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus.
Rey-Carrizo M, Barniol-Xicota M, Ma C, Frigolé-Vivas M, Torres E, Naesens L, Llabrés S, Juárez-Jiménez J, Luque FJ, DeGrado WF, Lamb RA, Pinto LH, Vázquez S. Rey-Carrizo M, et al. Among authors: vazquez s. J Med Chem. 2014 Jul 10;57(13):5738-47. doi: 10.1021/jm5005804. Epub 2014 Jun 30. J Med Chem. 2014. PMID: 24941437 Free PMC article.
738 results