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Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease.
J Med Chem. 2022 Mar 24;65(6):4909-4925. doi: 10.1021/acs.jmedchem.1c02150. Epub 2022 Mar 10.
J Med Chem. 2022.
PMID: 35271276
Free PMC article.
Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors.
Codony S, Entrena JM, Calvó-Tusell C, Jora B, González-Cano R, Osuna S, Corpas R, Morisseau C, Pérez B, Barniol-Xicota M, Griñán-Ferré C, Pérez C, Rodríguez-Franco MI, Martínez AL, Loza MI, Pallàs M, Verhelst SHL, Sanfeliu C, Feixas F, Hammock BD, Brea J, Cobos EJ, Vázquez S.
Codony S, et al. Among authors: calvo tusell c.
J Med Chem. 2022 Oct 27;65(20):13660-13680. doi: 10.1021/acs.jmedchem.2c00515. Epub 2022 Oct 12.
J Med Chem. 2022.
PMID: 36222708
Free PMC article.
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From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis.
Codony S, Calvó-Tusell C, Valverde E, Osuna S, Morisseau C, Loza MI, Brea J, Pérez C, Rodríguez-Franco MI, Pizarro-Delgado J, Corpas R, Griñán-Ferré C, Pallàs M, Sanfeliu C, Vázquez-Carrera M, Hammock BD, Feixas F, Vázquez S.
Codony S, et al. Among authors: calvo tusell c.
J Med Chem. 2021 May 13;64(9):5429-5446. doi: 10.1021/acs.jmedchem.0c01601. Epub 2021 May 4.
J Med Chem. 2021.
PMID: 33945278
Free PMC article.
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Time Evolution of the Millisecond Allosteric Activation of Imidazole Glycerol Phosphate Synthase.
Calvó-Tusell C, Maria-Solano MA, Osuna S, Feixas F.
Calvó-Tusell C, et al.
J Am Chem Soc. 2022 Apr 27;144(16):7146-7159. doi: 10.1021/jacs.1c12629. Epub 2022 Apr 12.
J Am Chem Soc. 2022.
PMID: 35412310
Free PMC article.
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In Vivo Selection for Formate Dehydrogenases with High Efficiency and Specificity toward NADP.
Calzadiaz-Ramirez L, Calvó-Tusell C, Stoffel GMM, Lindner SN, Osuna S, Erb TJ, Garcia-Borràs M, Bar-Even A, Acevedo-Rocha CG.
Calzadiaz-Ramirez L, et al. Among authors: calvo tusell c.
ACS Catal. 2020 Jul 17;10(14):7512-7525. doi: 10.1021/acscatal.0c01487. Epub 2020 Jun 8.
ACS Catal. 2020.
PMID: 32733773
Free PMC article.
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Dual-function enzyme catalysis for enantioselective carbon-nitrogen bond formation.
Liu Z, Calvó-Tusell C, Zhou AZ, Chen K, Garcia-Borràs M, Arnold FH.
Liu Z, et al. Among authors: calvo tusell c.
Nat Chem. 2021 Dec;13(12):1166-1172. doi: 10.1038/s41557-021-00794-z. Epub 2021 Oct 18.
Nat Chem. 2021.
PMID: 34663919
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Reversing the Enantioselectivity of Enzymatic Carbene N-H Insertion Through Mechanism-Guided Protein Engineering.
Calvó-Tusell C, Liu Z, Chen K, Arnold FH, Garcia-Borràs M.
Calvó-Tusell C, et al.
Angew Chem Int Ed Engl. 2023 Aug 28;62(35):e202303879. doi: 10.1002/anie.202303879. Epub 2023 Jul 20.
Angew Chem Int Ed Engl. 2023.
PMID: 37260412
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