Dror RO - Search Results

1

Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia.

Zhang K, Horikoshi N, Li S, Powers AS, Hameedi MA, Pintilie GD, Chae HD, Khan YA, Suomivuori CM, Dror RO, Sakamoto KM, Chiu W, Wakatsuki S. Zhang K, et al. Among authors: dror ro. ACS Cent Sci. 2022 Feb 23;8(2):214-222. doi: 10.1021/acscentsci.1c01090. Epub 2022 Feb 7. ACS Cent Sci. 2022. PMID: 35233453 Free PMC article.

2

Conformational transitions of a neurotensin receptor 1-G_i1 complex.

Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G. Kato HE, et al. Among authors: dror ro. Nature. 2019 Aug;572(7767):80-85. doi: 10.1038/s41586-019-1337-6. Epub 2019 Jun 26. Nature. 2019. PMID: 31243364 Free PMC article.

3

Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor.

Suomivuori CM, Latorraca NR, Wingler LM, Eismann S, King MC, Kleinhenz ALW, Skiba MA, Staus DP, Kruse AC, Lefkowitz RJ, Dror RO. Suomivuori CM, et al. Among authors: dror ro. Science. 2020 Feb 21;367(6480):881-887. doi: 10.1126/science.aaz0326. Science. 2020. PMID: 32079767 Free PMC article.

4

Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR.

Wingler LM, Skiba MA, McMahon C, Staus DP, Kleinhenz ALW, Suomivuori CM, Latorraca NR, Dror RO, Lefkowitz RJ, Kruse AC. Wingler LM, et al. Among authors: dror ro. Science. 2020 Feb 21;367(6480):888-892. doi: 10.1126/science.aay9813. Science. 2020. PMID: 32079768 Free PMC article.

5

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms.

Billesbølle CB, Azumaya CM, Kretsch RC, Powers AS, Gonen S, Schneider S, Arvedson T, Dror RO, Cheng Y, Manglik A. Billesbølle CB, et al. Among authors: dror ro. Nature. 2020 Oct;586(7831):807-811. doi: 10.1038/s41586-020-2668-z. Epub 2020 Aug 19. Nature. 2020. PMID: 32814342 Free PMC article.

6

How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling.

Latorraca NR, Masureel M, Hollingsworth SA, Heydenreich FM, Suomivuori CM, Brinton C, Townshend RJL, Bouvier M, Kobilka BK, Dror RO. Latorraca NR, et al. Among authors: dror ro. Cell. 2020 Dec 23;183(7):1813-1825.e18. doi: 10.1016/j.cell.2020.11.014. Epub 2020 Dec 8. Cell. 2020. PMID: 33296703 Free PMC article.

7

Selective G protein signaling driven by substance P-neurokinin receptor dynamics.

Harris JA, Faust B, Gondin AB, Dämgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A. Harris JA, et al. Among authors: dror ro. Nat Chem Biol. 2022 Jan;18(1):109-115. doi: 10.1038/s41589-021-00890-8. Epub 2021 Oct 28. Nat Chem Biol. 2022. PMID: 34711980 Free PMC article.

8

Leveraging nonstructural data to predict structures and affinities of protein-ligand complexes.

Paggi JM, Belk JA, Hollingsworth SA, Villanueva N, Powers AS, Clark MJ, Chemparathy AG, Tynan JE, Lau TK, Sunahara RK, Dror RO. Paggi JM, et al. Among authors: dror ro. Proc Natl Acad Sci U S A. 2021 Dec 21;118(51):e2112621118. doi: 10.1073/pnas.2112621118. Proc Natl Acad Sci U S A. 2021. PMID: 34921117 Free PMC article.

9

Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins.

Tsutsumi N, Maeda S, Qu Q, Vögele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC. Tsutsumi N, et al. Among authors: dror ro. Sci Adv. 2022 Jan 21;8(3):eabl5442. doi: 10.1126/sciadv.abl5442. Epub 2022 Jan 21. Sci Adv. 2022. PMID: 35061538 Free PMC article.

10

Autoantibody mimicry of hormone action at the thyrotropin receptor.

Faust B, Billesbølle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A. Faust B, et al. Among authors: dror ro. Nature. 2022 Sep;609(7928):846-853. doi: 10.1038/s41586-022-05159-1. Epub 2022 Aug 8. Nature. 2022. PMID: 35940205 Free PMC article.

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