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A rat model of Charcot-Marie-Tooth disease 1A recapitulates disease variability and supplies biomarkers of axonal loss in patients.
Fledrich R, Schlotter-Weigel B, Schnizer TJ, Wichert SP, Stassart RM, Meyer zu Hörste G, Klink A, Weiss BG, Haag U, Walter MC, Rautenstrauss B, Paulus W, Rossner MJ, Sereda MW. Fledrich R, et al. Among authors: stassart rm. Brain. 2012 Jan;135(Pt 1):72-87. doi: 10.1093/brain/awr322. Epub 2011 Dec 20. Brain. 2012. PMID: 22189569
Lithium enhances remyelination of peripheral nerves.
Makoukji J, Belle M, Meffre D, Stassart R, Grenier J, Shackleford G, Fledrich R, Fonte C, Branchu J, Goulard M, de Waele C, Charbonnier F, Sereda MW, Baulieu EE, Schumacher M, Bernard S, Massaad C. Makoukji J, et al. Among authors: stassart r. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3973-8. doi: 10.1073/pnas.1121367109. Epub 2012 Feb 21. Proc Natl Acad Sci U S A. 2012. PMID: 22355115 Free PMC article.
A role for Schwann cell-derived neuregulin-1 in remyelination.
Stassart RM, Fledrich R, Velanac V, Brinkmann BG, Schwab MH, Meijer D, Sereda MW, Nave KA. Stassart RM, et al. Nat Neurosci. 2013 Jan;16(1):48-54. doi: 10.1038/nn.3281. Epub 2012 Dec 9. Nat Neurosci. 2013. PMID: 23222914
Progesterone antagonist therapy in a Pelizaeus-Merzbacher mouse model.
Prukop T, Epplen DB, Nientiedt T, Wichert SP, Fledrich R, Stassart RM, Rossner MJ, Edgar JM, Werner HB, Nave KA, Sereda MW. Prukop T, et al. Among authors: stassart rm. Am J Hum Genet. 2014 Apr 3;94(4):533-46. doi: 10.1016/j.ajhg.2014.03.001. Epub 2014 Mar 27. Am J Hum Genet. 2014. PMID: 24680886 Free PMC article.
Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy.
Fledrich R, Abdelaal T, Rasch L, Bansal V, Schütza V, Brügger B, Lüchtenborg C, Prukop T, Stenzel J, Rahman RU, Hermes D, Ewers D, Möbius W, Ruhwedel T, Katona I, Weis J, Klein D, Martini R, Brück W, Müller WC, Bonn S, Bechmann I, Nave KA, Stassart RM, Sereda MW. Fledrich R, et al. Among authors: stassart rm. Nat Commun. 2018 Aug 2;9(1):3025. doi: 10.1038/s41467-018-05420-0. Nat Commun. 2018. PMID: 30072689 Free PMC article.
NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies.
Fledrich R, Akkermann D, Schütza V, Abdelaal TA, Hermes D, Schäffner E, Soto-Bernardini MC, Götze T, Klink A, Kusch K, Krueger M, Kungl T, Frydrychowicz C, Möbius W, Brück W, Mueller WC, Bechmann I, Sereda MW, Schwab MH, Nave KA, Stassart RM. Fledrich R, et al. Among authors: stassart rm. Nat Commun. 2019 Apr 1;10(1):1467. doi: 10.1038/s41467-019-09385-6. Nat Commun. 2019. PMID: 30931926 Free PMC article.
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