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Synthesis and Preclinical Characterization of LY3154885, a Human Dopamine D1 Receptor Positive Allosteric Modulator with an Improved Nonclinical Drug-Drug Interaction Risk Profile.
J Med Chem. 2022 Mar 10;65(5):3786-3797. doi: 10.1021/acs.jmedchem.1c01887. Epub 2022 Feb 17.
J Med Chem. 2022.
PMID: 35175768
Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor.
Hao J, Beck JP, Schaus JM, Krushinski JH, Chen Q, Beadle CD, Vidal P, Reinhard MR, Dressman BA, Massey SM, Boulet SL, Cohen MP, Watson BM, Tupper D, Gardinier KM, Myers J, Johansson AM, Richardson J, Richards DS, Hembre EJ, Remick DM, Coates DA, Bhardwaj RM, Diseroad BA, Bender D, Stephenson G, Wolfangel CD, Diaz N, Getman BG, Wang XS, Heinz BA, Cramer JW, Zhou X, Maren DL, Falcone JF, Wright RA, Mitchell SN, Carter G, Yang CR, Bruns RF, Svensson KA.
Hao J, et al. Among authors: remick dm.
J Med Chem. 2019 Oct 10;62(19):8711-8732. doi: 10.1021/acs.jmedchem.9b01234. Epub 2019 Sep 30.
J Med Chem. 2019.
PMID: 31532644
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Synthesis, crystallization, and biological evaluation of an orally active prodrug of gemcitabine.
Bender DM, Bao J, Dantzig AH, Diseroad WD, Law KL, Magnus NA, Peterson JA, Perkins EJ, Pu YJ, Reutzel-Edens SM, Remick DM, Starling JJ, Stephenson GA, Vaid RK, Zhang D, McCarthy JR.
Bender DM, et al. Among authors: remick dm.
J Med Chem. 2009 Nov 26;52(22):6958-61. doi: 10.1021/jm901181h.
J Med Chem. 2009.
PMID: 19860433
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Isolation and Physical Property Optimization of an Amorphous Drug Substance Utilizing a High Surface Area Magnesium Aluminometasilicate (Neusilin(®) US2).
Allgeier MC, Piper JL, Hinds J, Yates MH, Kolodsick KJ, Meury R, Shaw B, Kulkarni MR, Remick DM.
Allgeier MC, et al. Among authors: remick dm.
J Pharm Sci. 2016 Oct;105(10):3105-3114. doi: 10.1016/j.xphs.2016.06.019. Epub 2016 Aug 2.
J Pharm Sci. 2016.
PMID: 27492963
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An investigation into the influence of counterion on the properties of some amorphous organic salts.
Towler CS, Li T, Wikström H, Remick DM, Sanchez-Felix MV, Taylor LS.
Towler CS, et al. Among authors: remick dm.
Mol Pharm. 2008 Nov-Dec;5(6):946-55. doi: 10.1021/mp8000342.
Mol Pharm. 2008.
PMID: 19434850
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