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Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes.
DiNardo AR, Gandhi T, Heyckendorf J, Grimm SL, Rajapakshe K, Nishiguchi T, Reimann M, Kirchner HL, Kahari J, Dlamini Q, Lange C, Goldmann T, Marwitz S; DZIF-TB cohort study group; Abhimanyu, Cirillo JD, Kaufmann SHE, Netea MG, van Crevel R, Mandalakas AM, Coarfa C. DiNardo AR, et al. Among authors: nishiguchi t. Eur Respir J. 2022 Sep 15;60(3):2102263. doi: 10.1183/13993003.02263-2021. Print 2022 Sep. Eur Respir J. 2022. PMID: 35169026 Free PMC article.
Tuberculosis endotypes to guide stratified host-directed therapy.
DiNardo AR, Nishiguchi T, Grimm SL, Schlesinger LS, Graviss EA, Cirillo JD, Coarfa C, Mandalakas AM, Heyckendorf J, Kaufmann SHE, Lange C, Netea MG, Van Crevel R. DiNardo AR, et al. Among authors: nishiguchi t. Med. 2021 Mar 12;2(3):217-232. doi: 10.1016/j.medj.2020.11.003. Epub 2021 Jan 16. Med. 2021. PMID: 34693385 Free PMC article.
Increased DNA methylation, cellular senescence and premature epigenetic aging in guinea pigs and humans with tuberculosis.
Bobak CA, Abhimanyu, Natarajan H, Gandhi T, Grimm SL, Nishiguchi T, Koster K, Longlax SC, Dlamini Q, Kahari J, Mtetwa G, Cirillo JD, O'Malley J, Hill JE, Coarfa C, DiNardo AR. Bobak CA, et al. Among authors: nishiguchi t. Aging (Albany NY). 2022 Mar 7;14(5):2174-2193. doi: 10.18632/aging.203936. Epub 2022 Mar 7. Aging (Albany NY). 2022. PMID: 35256539 Free PMC article.
Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-Specific Immune Changes.
DiNardo AR, Nishiguchi T, Mace EM, Rajapakshe K, Mtetwa G, Kay A, Maphalala G, Secor WE, Mejia R, Orange JS, Coarfa C, Bhalla KN, Graviss EA, Mandalakas AM, Makedonas G. DiNardo AR, et al. Among authors: nishiguchi t. J Immunol. 2018 Jul 1;201(1):124-133. doi: 10.4049/jimmunol.1800101. Epub 2018 May 11. J Immunol. 2018. PMID: 29752313 Free PMC article.
DNA hypermethylation during tuberculosis dampens host immune responsiveness.
DiNardo AR, Rajapakshe K, Nishiguchi T, Grimm SL, Mtetwa G, Dlamini Q, Kahari J, Mahapatra S, Kay A, Maphalala G, Mace EM, Makedonas G, Cirillo JD, Netea MG, van Crevel R, Coarfa C, Mandalakas AM. DiNardo AR, et al. Among authors: nishiguchi t. J Clin Invest. 2020 Jun 1;130(6):3113-3123. doi: 10.1172/JCI134622. J Clin Invest. 2020. PMID: 32125282 Free PMC article.
Perspective for Precision Medicine for Tuberculosis.
Lange C, Aarnoutse R, Chesov D, van Crevel R, Gillespie SH, Grobbel HP, Kalsdorf B, Kontsevaya I, van Laarhoven A, Nishiguchi T, Mandalakas A, Merker M, Niemann S, Köhler N, Heyckendorf J, Reimann M, Ruhwald M, Sanchez-Carballo P, Schwudke D, Waldow F, DiNardo AR. Lange C, et al. Among authors: nishiguchi t. Front Immunol. 2020 Oct 8;11:566608. doi: 10.3389/fimmu.2020.566608. eCollection 2020. Front Immunol. 2020. PMID: 33117351 Free PMC article. Review.
Reversing Post-Infectious Epigenetic-Mediated Immune Suppression.
Abhimanyu, Ontiveros CO, Guerra-Resendez RS, Nishiguchi T, Ladki M, Hilton IB, Schlesinger LS, DiNardo AR. Abhimanyu, et al. Among authors: nishiguchi t. Front Immunol. 2021 Jun 7;12:688132. doi: 10.3389/fimmu.2021.688132. eCollection 2021. Front Immunol. 2021. PMID: 34163486 Free PMC article. Review.
207 results