Metformin protects against ischaemic myocardial injury by alleviating autophagy-ROS-NLRP3-mediated inflammatory response in macrophages.
Fei Q, Ma H, Zou J, Wang W, Zhu L, Deng H, Meng M, Tan S, Zhang H, Xiao X, Wang N, Wang K.
Fei Q, et al. Among authors: ma h.
J Mol Cell Cardiol. 2020 Aug;145:1-13. doi: 10.1016/j.yjmcc.2020.05.016. Epub 2020 May 26.
J Mol Cell Cardiol. 2020.
PMID: 32470468
Additionally, both conditioned medium from H9c2 cardiomyocytes exposed to hydrogen peroxide (H9c2-H(2)O(2)-CM) and combination of mtDNA and ATP (mtDNA-ATP) increased the expression of NLRP3 and cleaved caspase-1 (p10) as well as intracellular ROS production in RAW264.7 mac …
Additionally, both conditioned medium from H9c2 cardiomyocytes exposed to hydrogen peroxide (H9c2-H(2)O(2)-CM) and combination of mtD …