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Initial properdin binding contributes to alternative pathway activation at the surface of viable and necrotic cells.
van Essen MF, Schlagwein N, van den Hoven EMP, van Gijlswijk-Janssen DJ, Lubbers R, van den Bos RM, van den Born J, Ruben JM, Trouw LA, van Kooten C; COMBAT consortium. van Essen MF, et al. Among authors: lubbers r. Eur J Immunol. 2022 Apr;52(4):597-608. doi: 10.1002/eji.202149259. Epub 2022 Feb 17. Eur J Immunol. 2022. PMID: 35092629 Free PMC article.
Complement Component C1q as Serum Biomarker to Detect Active Tuberculosis.
Lubbers R, Sutherland JS, Goletti D, de Paus RA, van Moorsel CHM, Veltkamp M, Vestjens SMT, Bos WJW, Petrone L, Del Nonno F, Bajema IM, Dijkman K, Verreck FAW, Walzl G, Gelderman KA, Groeneveld GH, Geluk A, Ottenhoff THM, Joosten SA, Trouw LA. Lubbers R, et al. Front Immunol. 2018 Oct 23;9:2427. doi: 10.3389/fimmu.2018.02427. eCollection 2018. Front Immunol. 2018. PMID: 30405622 Free PMC article.
Expression and production of the SERPING1-encoded endogenous complement regulator C1-inhibitor in multiple cohorts of tuberculosis patients.
Lubbers R, Sutherland JS, Goletti D, de Paus RA, Dijkstra DJ, van Moorsel CHM, Veltkamp M, Vestjens SMT, Bos WJW, Petrone L, Malherbe ST, Walzl G, Gelderman KA, Groeneveld GH, Geluk A, Ottenhoff THM, Joosten SA, Trouw LA. Lubbers R, et al. Mol Immunol. 2020 Apr;120:187-195. doi: 10.1016/j.molimm.2020.02.006. Epub 2020 Mar 13. Mol Immunol. 2020. PMID: 32179338 Free article.
Carbamylation reduces the capacity of IgG for hexamerization and complement activation.
Lubbers R, Oostindie SC, Dijkstra DJ, Parren PWHI, Verheul MK, Abendstein L, Sharp TH, de Ru A, Janssen GMC, van Veelen PA, van den Bremer ETJ, Bleijlevens B, de Kreuk BJ, Beurskens FJ, Trouw LA. Lubbers R, et al. Clin Exp Immunol. 2020 Apr;200(1):1-11. doi: 10.1111/cei.13411. Epub 2020 Jan 5. Clin Exp Immunol. 2020. PMID: 31853959 Free PMC article.
Complement component C1q is produced by isolated articular chondrocytes.
Lubbers R, van Schaarenburg RA, Kwekkeboom JC, Levarht EWN, Bakker AM, Mahdad R, Monteagudo S, Cherifi C, Lories RJ, Toes REM, Ioan-Facsinay A, Trouw LA. Lubbers R, et al. Osteoarthritis Cartilage. 2020 May;28(5):675-684. doi: 10.1016/j.joca.2019.09.007. Epub 2019 Oct 18. Osteoarthritis Cartilage. 2020. PMID: 31634584 Free article.
Complex medical history of a patient with a compound heterozygous mutation in C1QC.
Lubbers R, Beaart-van de Voorde LJJ, van Leeuwen K, de Boer M, Gelderman KA, van den Berg MJ, Ketel AG, Simon A, de Ree J, Huizinga TWJ, Steup-Beekman GM, Trouw LA. Lubbers R, et al. Lupus. 2019 Sep;28(10):1255-1260. doi: 10.1177/0961203319865029. Epub 2019 Jul 29. Lupus. 2019. PMID: 31357913 Free PMC article.
Genetic deficiency of NOD2 confers resistance to invasive aspergillosis.
Gresnigt MS, Cunha C, Jaeger M, Gonçalves SM, Malireddi RKS, Ammerdorffer A, Lubbers R, Oosting M, Rasid O, Jouvion G, Fitting C, Jong DJ, Lacerda JF, Campos A Jr, Melchers WJG, Lagrou K, Maertens J, Kanneganti TD, Carvalho A, Ibrahim-Granet O, van de Veerdonk FL. Gresnigt MS, et al. Among authors: lubbers r. Nat Commun. 2018 Jul 6;9(1):2636. doi: 10.1038/s41467-018-04912-3. Nat Commun. 2018. PMID: 29980664 Free PMC article.
32 results