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Therapeutic treatment with the anti-inflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorbid amyloid and vascular pathology.
Braun DJ, Powell DK, McLouth CJ, Roy SM, Watterson DM, Van Eldik LJ. Braun DJ, et al. Among authors: powell dk. PLoS One. 2022 Jan 26;17(1):e0262474. doi: 10.1371/journal.pone.0262474. eCollection 2022. PLoS One. 2022. PMID: 35081152 Free PMC article.
Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia.
Niedowicz DM, Reeves VL, Platt TL, Kohler K, Beckett TL, Powell DK, Lee TL, Sexton TR, Song ES, Brewer LD, Latimer CS, Kraner SD, Larson KL, Ozcan S, Norris CM, Hersh LB, Porter NM, Wilcock DM, Murphy MP. Niedowicz DM, et al. Among authors: powell dk. Acta Neuropathol Commun. 2014 Jun 10;2:64. doi: 10.1186/2051-5960-2-64. Acta Neuropathol Commun. 2014. PMID: 24916066 Free PMC article.
The effects of mild closed head injuries on tauopathy and cognitive deficits in rodents: Primary results in wild type and rTg4510 mice, and a systematic review.
Bachstetter AD, Morganti JM, Bodnar CN, Webster SJ, Higgins EK, Roberts KN, Snider H, Meier SE, Nation GK, Goulding DS, Hamm M, Powell DK, Vandsburger M, Van Eldik LJ, Abisambra JF. Bachstetter AD, et al. Among authors: powell dk. Exp Neurol. 2020 Apr;326:113180. doi: 10.1016/j.expneurol.2020.113180. Epub 2020 Jan 11. Exp Neurol. 2020. PMID: 31930992 Free PMC article.
Development of a protocol to assess within-subject, regional white matter hyperintensity changes in aging and dementia.
Bahrani AA, Smith CD, Barber JM, Al-Janabi OM, Powell DK, Andersen AH, Ramey BD, Abner EL, Goldstein LB, Winder Z, Gold BT, Van Eldik L, Wilcock DM, Jicha GA. Bahrani AA, et al. Among authors: powell dk. J Neurosci Methods. 2021 Aug 1;360:109270. doi: 10.1016/j.jneumeth.2021.109270. Epub 2021 Jun 24. J Neurosci Methods. 2021. PMID: 34171312 Free PMC article.
Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy.
Koren SA, Hamm MJ, Cloyd R, Fontaine SN, Chishti E, Lanzillotta C, Rodriguez-Rivera J, Ingram A, Bell M, Galvis-Escobar SM, Zulia N, Di Domenico F, Duong D, Seyfried NT, Powell D, Vandsburger M, Frolinger T, Hartz AMS, Koren J 3rd, Axten JM, Laping NJ, Abisambra JF. Koren SA, et al. Int J Mol Sci. 2021 Jan 26;22(3):1186. doi: 10.3390/ijms22031186. Int J Mol Sci. 2021. PMID: 33530349 Free PMC article.
Targeting Astrocyte Signaling Alleviates Cerebrovascular and Synaptic Function Deficits in a Diet-Based Mouse Model of Small Cerebral Vessel Disease.
Sompol P, Gollihue JL, Weiss BE, Lin RL, Case SL, Kraner SD, Weekman EM, Gant JC, Rogers CB, Niedowicz DM, Sudduth TL, Powell DK, Lin AL, Nelson PT, Thibault O, Wilcock DM, Norris CM. Sompol P, et al. Among authors: powell dk. J Neurosci. 2023 Mar 8;43(10):1797-1813. doi: 10.1523/JNEUROSCI.1333-22.2023. Epub 2023 Feb 6. J Neurosci. 2023. PMID: 36746627 Free PMC article.
Identification of changes in neuronal function as a consequence of aging and tauopathic neurodegeneration using a novel and sensitive magnetic resonance imaging approach.
Fontaine SN, Ingram A, Cloyd RA, Meier SE, Miller E, Lyons D, Nation GK, Mechas E, Weiss B, Lanzillotta C, Di Domenico F, Schmitt F, Powell DK, Vandsburger M, Abisambra JF. Fontaine SN, et al. Among authors: powell dk. Neurobiol Aging. 2017 Aug;56:78-86. doi: 10.1016/j.neurobiolaging.2017.04.007. Epub 2017 Apr 18. Neurobiol Aging. 2017. PMID: 28500878 Free PMC article.
94 results