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Pro108Ser mutation of SARS-CoV-2 3CLpro reduces the enzyme activity and ameliorates the clinical severity of COVID-19.
Abe K, Kabe Y, Uchiyama S, Iwasaki YW, Ishizu H, Uwamino Y, Takenouchi T, Uno S, Ishii M, Maruno T, Noda M, Murata M, Hasegawa N, Saya H, Kitagawa Y, Fukunaga K, Amagai M, Siomi H, Suematsu M, Kosaki K; Keio Donner Project. Abe K, et al. Among authors: uchiyama s. Sci Rep. 2022 Jan 25;12(1):1299. doi: 10.1038/s41598-022-05424-3. Sci Rep. 2022. PMID: 35079088 Free PMC article.
Structural Basis for Dimer Formation of Human Condensin Structural Maintenance of Chromosome Proteins and Its Implications for Single-stranded DNA Recognition.
Uchiyama S, Kawahara K, Hosokawa Y, Fukakusa S, Oki H, Nakamura S, Kojima Y, Noda M, Takino R, Miyahara Y, Maruno T, Kobayashi Y, Ohkubo T, Fukui K. Uchiyama S, et al. J Biol Chem. 2015 Dec 4;290(49):29461-77. doi: 10.1074/jbc.M115.670794. Epub 2015 Oct 20. J Biol Chem. 2015. PMID: 26491021 Free PMC article.
Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance.
Kabe Y, Nakane T, Koike I, Yamamoto T, Sugiura Y, Harada E, Sugase K, Shimamura T, Ohmura M, Muraoka K, Yamamoto A, Uchida T, Iwata S, Yamaguchi Y, Krayukhina E, Noda M, Handa H, Ishimori K, Uchiyama S, Kobayashi T, Suematsu M. Kabe Y, et al. Among authors: uchiyama s. Nat Commun. 2016 Mar 18;7:11030. doi: 10.1038/ncomms11030. Nat Commun. 2016. PMID: 26988023 Free PMC article.
1,294 results