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Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring.
Bioorg Med Chem Lett. 2022 Mar 15;60:128555. doi: 10.1016/j.bmcl.2022.128555. Epub 2022 Jan 17.
Bioorg Med Chem Lett. 2022.
PMID: 35051577
Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library.
Saitoh T, Amezawa M, Horiuchi J, Nagumo Y, Yamamoto N, Kutsumura N, Ohshita R, Tokuda A, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Hasegawa E, Sakurai T, Uchida Y, Sato T, Gouda H, Tanimura R, Yanagisawa M, Nagase H.
Saitoh T, et al. Among authors: ohshita r.
Eur J Med Chem. 2022 Oct 5;240:114505. doi: 10.1016/j.ejmech.2022.114505. Epub 2022 Jun 13.
Eur J Med Chem. 2022.
PMID: 35839689
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