Nagase H - Search Results

1

Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring.

Iio K, Saitoh T, Ohshita R, Hino T, Amezawa M, Takayama Y, Nagumo Y, Yamamoto N, Kutsumura N, Irukayama-Tomobe Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H. Iio K, et al. Among authors: nagase h. Bioorg Med Chem Lett. 2022 Mar 15;60:128555. doi: 10.1016/j.bmcl.2022.128555. Epub 2022 Jan 17. Bioorg Med Chem Lett. 2022. PMID: 35051577

2

Drug design and synthesis of epsilon opioid receptor agonist: 17-(cyclopropylmethyl)-4,5alpha-epoxy-3,6beta-dihydroxy-6,14-endoethenomorphinan-7alpha-(N-methyl-N-phenethyl)carboxamide (TAN-821) inducing antinociception mediated by putative epsilon opioid receptor.

Fujii H, Narita M, Mizoguchi H, Murachi M, Tanaka T, Kawai K, Tseng LF, Nagase H. Fujii H, et al. Among authors: nagase h. Bioorg Med Chem. 2004 Aug 1;12(15):4133-45. doi: 10.1016/j.bmc.2004.05.024. Bioorg Med Chem. 2004. PMID: 15246090

3

Rational drug design and synthesis of a selective opioid receptor antagonist on the basis of the accessory site concept.

Fujii H, Narita M, Mizoguchi H, Hirokawa J, Kawai K, Tanaka T, Tseng LF, Nagase H. Fujii H, et al. Among authors: nagase h. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4241-3. doi: 10.1016/j.bmcl.2004.06.004. Bioorg Med Chem Lett. 2004. PMID: 15261278

4

Rational drug design of selective epsilon opioid receptor agonist TAN-821 and antagonist TAN-1014.

Fujii H, Nagase H. Fujii H, et al. Among authors: nagase h. Curr Med Chem. 2006;13(10):1109-18. doi: 10.2174/092986706776360851. Curr Med Chem. 2006. PMID: 16719773 Review.

5

Syntheses of 4,6'-epoxymorphinan derivatives and their pharmacologies.

Nemoto T, Fujii H, Narita M, Miyoshi K, Nakamura A, Suzuki T, Nagase H. Nemoto T, et al. Among authors: nagase h. Bioorg Med Chem. 2008 Apr 15;16(8):4304-12. doi: 10.1016/j.bmc.2008.02.082. Epub 2008 Feb 29. Bioorg Med Chem. 2008. PMID: 18337104

6

Structure-antitussive activity relationships of naltrindole derivatives. Identification of novel and potent antitussive agents.

Sakami S, Maeda M, Kawai K, Aoki T, Kawamura K, Fujii H, Hasebe K, Nakajima M, Endo T, Ueno S, Ito T, Kamei J, Nagase H. Sakami S, et al. Among authors: nagase h. J Med Chem. 2008 Aug 14;51(15):4404-11. doi: 10.1021/jm701440h. Epub 2008 Jul 19. J Med Chem. 2008. PMID: 18637671

7

Design and synthesis of a metabolically stable and potent antitussive agent, a novel delta opioid receptor antagonist, TRK-851.

Sakami S, Kawai K, Maeda M, Aoki T, Fujii H, Ohno H, Ito T, Saitoh A, Nakao K, Izumimoto N, Matsuura H, Endo T, Ueno S, Natsume K, Nagase H. Sakami S, et al. Among authors: nagase h. Bioorg Med Chem. 2008 Sep 1;16(17):7956-67. doi: 10.1016/j.bmc.2008.07.065. Epub 2008 Jul 29. Bioorg Med Chem. 2008. PMID: 18701308

8

Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction.

Fujii H, Osa Y, Ishihara M, Hanamura S, Nemoto T, Nakajima M, Hasebe K, Mochizuki H, Nagase H. Fujii H, et al. Among authors: nagase h. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4978-81. doi: 10.1016/j.bmcl.2008.08.019. Epub 2008 Aug 12. Bioorg Med Chem Lett. 2008. PMID: 18755589

9

Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists.

Kawai K, Hayakawa J, Miyamoto T, Imamura Y, Yamane S, Wakita H, Fujii H, Kawamura K, Matsuura H, Izumimoto N, Kobayashi R, Endo T, Nagase H. Kawai K, et al. Among authors: nagase h. Bioorg Med Chem. 2008 Oct 15;16(20):9188-201. doi: 10.1016/j.bmc.2008.09.011. Epub 2008 Sep 9. Bioorg Med Chem. 2008. PMID: 18829333

10

Design and synthesis of novel delta opioid receptor agonists and their pharmacologies.

Nagase H, Osa Y, Nemoto T, Fujii H, Imai M, Nakamura T, Kanemasa T, Kato A, Gouda H, Hirono S. Nagase H, et al. Bioorg Med Chem Lett. 2009 May 15;19(10):2792-5. doi: 10.1016/j.bmcl.2009.03.099. Epub 2009 Mar 26. Bioorg Med Chem Lett. 2009. PMID: 19362480

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