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Page 1
Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring.
Iio K, Saitoh T, Ohshita R, Hino T, Amezawa M, Takayama Y, Nagumo Y, Yamamoto N, Kutsumura N, Irukayama-Tomobe Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H. Iio K, et al. Among authors: ishikawa y. Bioorg Med Chem Lett. 2022 Mar 15;60:128555. doi: 10.1016/j.bmcl.2022.128555. Epub 2022 Jan 17. Bioorg Med Chem Lett. 2022. PMID: 35051577
Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies.
Nagase H, Yamamoto N, Yata M, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ishikawa Y, Ogawa Y, Hirayama S, Kuroda D, Watanabe Y, Gouda H, Yanagisawa M. Nagase H, et al. Among authors: ishikawa y. J Med Chem. 2017 Feb 9;60(3):1018-1040. doi: 10.1021/acs.jmedchem.6b01418. Epub 2017 Jan 18. J Med Chem. 2017. PMID: 28051300
Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models.
Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M. Irukayama-Tomobe Y, et al. Among authors: ishikawa y. Proc Natl Acad Sci U S A. 2017 May 30;114(22):5731-5736. doi: 10.1073/pnas.1700499114. Epub 2017 May 15. Proc Natl Acad Sci U S A. 2017. PMID: 28507129 Free PMC article.
Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor.
Yamamoto N, Ohrui S, Okada T, Yata M, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H. Yamamoto N, et al. Among authors: ishikawa y. Bioorg Med Chem Lett. 2017 Sep 1;27(17):4176-4179. doi: 10.1016/j.bmcl.2017.07.011. Epub 2017 Jul 4. Bioorg Med Chem Lett. 2017. PMID: 28739044
Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity.
Ohrui S, Yamamoto N, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H. Ohrui S, et al. Among authors: ishikawa y. Bioorg Med Chem Lett. 2018 Feb 15;28(4):774-777. doi: 10.1016/j.bmcl.2017.12.069. Epub 2017 Dec 30. Bioorg Med Chem Lett. 2018. PMID: 29338909
Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring.
Yamamoto N, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H. Yamamoto N, et al. Among authors: ishikawa y. Bioorg Med Chem. 2019 Apr 15;27(8):1747-1758. doi: 10.1016/j.bmc.2019.03.010. Epub 2019 Mar 5. Bioorg Med Chem. 2019. PMID: 30871861
Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity.
Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H. Saitoh T, et al. Among authors: ishikawa y. Bioorg Med Chem Lett. 2019 Sep 15;29(18):2655-2658. doi: 10.1016/j.bmcl.2019.07.039. Epub 2019 Jul 24. Bioorg Med Chem Lett. 2019. PMID: 31375290
Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group.
Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Yanagisawa M, Nagase H. Saitoh T, et al. Among authors: ishikawa y. Bioorg Med Chem Lett. 2020 Feb 1;30(3):126893. doi: 10.1016/j.bmcl.2019.126893. Epub 2019 Dec 17. Bioorg Med Chem Lett. 2020. PMID: 31879208
Structure of cortical network activity across natural wake and sleep states in mice.
Ohyama K, Kanda T, Miyazaki T, Tsujino N, Ishii R, Ishikawa Y, Muramoto H, Grenier F, Makino Y, McHugh TJ, Yanagisawa M, Greene RW, Vogt KE. Ohyama K, et al. Among authors: ishikawa y. PLoS One. 2020 May 29;15(5):e0233561. doi: 10.1371/journal.pone.0233561. eCollection 2020. PLoS One. 2020. PMID: 32470016 Free PMC article.
3,682 results