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Ablation of the canonical testosterone production pathway via knockout of the steroidogenic enzyme HSD17B3, reveals a novel mechanism of testicular testosterone production.
Rebourcet D, Mackay R, Darbey A, Curley MK, Jørgensen A, Frederiksen H, Mitchell RT, O'Shaughnessy PJ, Nef S, Smith LB. Rebourcet D, et al. Among authors: darbey a. FASEB J. 2020 Aug;34(8):10373-10386. doi: 10.1096/fj.202000361R. Epub 2020 Jun 18. FASEB J. 2020. PMID: 32557858 Free PMC article.
A Novel Model Using AAV9-Cre to Knockout Adult Leydig Cell Gene Expression Reveals a Physiological Role of Glucocorticoid Receptor Signalling in Leydig Cell Function.
Gannon AL, Darbey AL, Chensee G, Lawrence BM, O'Donnell L, Kelso J, Reed N, Parameswaran S, Smith S, Smith LB, Rebourcet D. Gannon AL, et al. Among authors: darbey al. Int J Mol Sci. 2022 Nov 30;23(23):15015. doi: 10.3390/ijms232315015. Int J Mol Sci. 2022. PMID: 36499341 Free PMC article.
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