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Mutagenesis of the dengue virus type 2 NS5 methyltransferase domain.
Kroschewski H, Lim SP, Butcher RE, Yap TL, Lescar J, Wright PJ, Vasudevan SG, Davidson AD. Kroschewski H, et al. Among authors: lescar j. J Biol Chem. 2008 Jul 11;283(28):19410-21. doi: 10.1074/jbc.M800613200. Epub 2008 May 9. J Biol Chem. 2008. PMID: 18469001 Free article.
Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications.
Luo D, Wei N, Doan DN, Paradkar PN, Chong Y, Davidson AD, Kotaka M, Lescar J, Vasudevan SG. Luo D, et al. Among authors: lescar j. J Biol Chem. 2010 Jun 11;285(24):18817-27. doi: 10.1074/jbc.M109.090936. Epub 2010 Apr 7. J Biol Chem. 2010. PMID: 20375022 Free PMC article.
The structure at 3.15 A of the soluble NS3 protein from DENV4 covalently attached to 18 residues of the NS2B cofactor region (NS2B(18)NS3) revealed an elongated molecule with the protease domain abutting subdomains I and II of the helicase (Luo, D., Xu, T., Hunke, C., Gruber, G., …
The structure at 3.15 A of the soluble NS3 protein from DENV4 covalently attached to 18 residues of the NS2B cofactor region (NS2B(18)NS3) r …
Small molecule inhibitors that selectively block dengue virus methyltransferase.
Lim SP, Sonntag LS, Noble C, Nilar SH, Ng RH, Zou G, Monaghan P, Chung KY, Dong H, Liu B, Bodenreider C, Lee G, Ding M, Chan WL, Wang G, Jian YL, Chao AT, Lescar J, Yin Z, Vedananda TR, Keller TH, Shi PY. Lim SP, et al. Among authors: lescar j. J Biol Chem. 2011 Feb 25;286(8):6233-40. doi: 10.1074/jbc.M110.179184. Epub 2010 Dec 8. J Biol Chem. 2011. PMID: 21147775 Free PMC article.
Functional analysis of two cavities in flavivirus NS5 polymerase.
Zou G, Chen YL, Dong H, Lim CC, Yap LJ, Yau YH, Shochat SG, Lescar J, Shi PY. Zou G, et al. Among authors: lescar j. J Biol Chem. 2011 Apr 22;286(16):14362-72. doi: 10.1074/jbc.M110.214189. Epub 2011 Feb 23. J Biol Chem. 2011. PMID: 21349834 Free PMC article.
178 results