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SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics.
Ramachandran K, Maity S, Muthukumar AR, Kandala S, Tomar D, Abd El-Aziz TM, Allen C, Sun Y, Venkatesan M, Madaris TR, Chiem K, Truitt R, Vishnu N, Aune G, Anderson A, Martinez-Sobrido L, Yang W, Stockand JD, Singh BB, Srikantan S, Reeves WB, Madesh M. Ramachandran K, et al. Among authors: madesh m. iScience. 2022 Jan 1;25(1):103722. doi: 10.1016/j.isci.2021.103722. eCollection 2022 Jan 21. iScience. 2022. PMID: 35005527 Free PMC article.
Methylene blue counteracts cyanide cardiotoxicity: cellular mechanisms.
Cheung JY, Wang J, Zhang XQ, Song J, Tomar D, Madesh M, Judenherc-Haouzi A, Haouzi P. Cheung JY, et al. Among authors: madesh m. J Appl Physiol (1985). 2018 May 1;124(5):1164-1176. doi: 10.1152/japplphysiol.00967.2017. Epub 2018 Feb 8. J Appl Physiol (1985). 2018. PMID: 29420146 Free PMC article.
FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation.
Shanmughapriya S, Tomar D, Dong Z, Slovik KJ, Nemani N, Natarajaseenivasan K, Carvalho E, Lu C, Corrigan K, Garikipati VNS, Ibetti J, Rajan S, Barrero C, Chuprun K, Kishore R, Merali S, Tian Y, Yang W, Madesh M. Shanmughapriya S, et al. Among authors: madesh m. Nat Commun. 2018 Aug 29;9(1):3449. doi: 10.1038/s41467-018-05856-4. Nat Commun. 2018. PMID: 30158529 Free PMC article.
A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury.
Woods JJ, Nemani N, Shanmughapriya S, Kumar A, Zhang M, Nathan SR, Thomas M, Carvalho E, Ramachandran K, Srikantan S, Stathopulos PB, Wilson JJ, Madesh M. Woods JJ, et al. Among authors: madesh m. ACS Cent Sci. 2019 Jan 23;5(1):153-166. doi: 10.1021/acscentsci.8b00773. Epub 2019 Jan 4. ACS Cent Sci. 2019. PMID: 30693334 Free PMC article.
Blockade of MCU-Mediated Ca2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation.
Tomar D, Jaña F, Dong Z, Quinn WJ 3rd, Jadiya P, Breves SL, Daw CC, Srikantan S, Shanmughapriya S, Nemani N, Carvalho E, Tripathi A, Worth AM, Zhang X, Razmpour R, Seelam A, Rhode S, Mehta AV, Murray M, Slade D, Ramirez SH, Mishra P, Gerhard GS, Caplan J, Norton L, Sharma K, Rajan S, Balciunas D, Wijesinghe DS, Ahima RS, Baur JA, Madesh M. Tomar D, et al. Among authors: madesh m. Cell Rep. 2019 Mar 26;26(13):3709-3725.e7. doi: 10.1016/j.celrep.2019.02.107. Cell Rep. 2019. PMID: 30917323 Free PMC article.
MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome.
Qiu Z, Lin AP, Jiang S, Elkashef SM, Myers J, Srikantan S, Sasi B, Cao JZ, Godley LA, Rakheja D, Lyu Y, Zheng S, Madesh M, Shiio Y, Dahia PLM, Aguiar RCT. Qiu Z, et al. Among authors: madesh m. Cell Chem Biol. 2020 May 21;27(5):538-550.e7. doi: 10.1016/j.chembiol.2020.02.002. Epub 2020 Feb 25. Cell Chem Biol. 2020. PMID: 32101699 Free PMC article.
Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity.
Nemani N, Dong Z, Daw CC, Madaris TR, Ramachandran K, Enslow BT, Rubannelsonkumar CS, Shanmughapriya S, Mallireddigari V, Maity S, SinghMalla P, Natarajanseenivasan K, Hooper R, Shannon CE, Tourtellotte WG, Singh BB, Reeves WB, Sharma K, Norton L, Srikantan S, Soboloff J, Madesh M. Nemani N, et al. Among authors: madesh m. Sci Signal. 2020 Apr 21;13(628):eaaz6206. doi: 10.1126/scisignal.aaz6206. Sci Signal. 2020. PMID: 32317369 Free PMC article.
176 results