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Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site.
Liu Z, Li Y, Chen H, Lai HT, Wang P, Wu SY, Wold EA, Leonard PG, Joseph S, Hu H, Chiang CM, Brasier AR, Tian B, Zhou J. Liu Z, et al. Among authors: chen h. J Med Chem. 2022 Feb 10;65(3):2388-2408. doi: 10.1021/acs.jmedchem.1c01851. Epub 2022 Jan 4. J Med Chem. 2022. PMID: 34982556 Free PMC article.
Targeting Krüppel-like factor 5 (KLF5) for cancer therapy.
Gao Y, Ding Y, Chen H, Chen H, Zhou J. Gao Y, et al. Among authors: chen h. Curr Top Med Chem. 2015;15(8):699-713. doi: 10.2174/1568026615666150302105052. Curr Top Med Chem. 2015. PMID: 25732792 Review.
Structure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists.
Ye N, Zhu Y, Chen H, Liu Z, Mei FC, Wild C, Chen H, Cheng X, Zhou J. Ye N, et al. Among authors: chen h. J Med Chem. 2015 Aug 13;58(15):6033-47. doi: 10.1021/acs.jmedchem.5b00635. Epub 2015 Jul 16. J Med Chem. 2015. PMID: 26151319 Free PMC article.
Direct Activation of Bax Protein for Cancer Therapy.
Liu Z, Ding Y, Ye N, Wild C, Chen H, Zhou J. Liu Z, et al. Among authors: chen h. Med Res Rev. 2016 Mar;36(2):313-41. doi: 10.1002/med.21379. Epub 2015 Sep 23. Med Res Rev. 2016. PMID: 26395559 Free PMC article. Review.
BH4 domain of Bcl-2 as a novel target for cancer therapy.
Liu Z, Wild C, Ding Y, Ye N, Chen H, Wold EA, Zhou J. Liu Z, et al. Among authors: chen h. Drug Discov Today. 2016 Jun;21(6):989-96. doi: 10.1016/j.drudis.2015.11.008. Epub 2015 Nov 26. Drug Discov Today. 2016. PMID: 26631752 Free PMC article. Review.
Functionalized N,N-Diphenylamines as Potent and Selective EPAC2 Inhibitors.
Wild CT, Zhu Y, Na Y, Mei F, Ynalvez MA, Chen H, Cheng X, Zhou J. Wild CT, et al. Among authors: chen h. ACS Med Chem Lett. 2016 Mar 28;7(5):460-4. doi: 10.1021/acsmedchemlett.5b00477. eCollection 2016 May 12. ACS Med Chem Lett. 2016. PMID: 27190593 Free PMC article.
Therapeutic Potential of Spirooxindoles as Antiviral Agents.
Ye N, Chen H, Wold EA, Shi PY, Zhou J. Ye N, et al. Among authors: chen h. ACS Infect Dis. 2016 Jun 10;2(6):382-92. doi: 10.1021/acsinfecdis.6b00041. Epub 2016 May 5. ACS Infect Dis. 2016. PMID: 27627626 Free PMC article. Review.
Drug Discovery Targeting Bromodomain-Containing Protein 4.
Liu Z, Wang P, Chen H, Wold EA, Tian B, Brasier AR, Zhou J. Liu Z, et al. Among authors: chen h. J Med Chem. 2017 Jun 8;60(11):4533-4558. doi: 10.1021/acs.jmedchem.6b01761. Epub 2017 Mar 2. J Med Chem. 2017. PMID: 28195723 Free PMC article. Review.
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