Buckley B - Search Results

1

Roles of the Na⁺/H⁺ Exchanger Isoform 1 and Urokinase in Prostate Cancer Cell Migration and Invasion.

Li X, Buckley B, Stoletov K, Jing Y, Ranson M, Lewis JD, Kelso M, Fliegel L. Li X, et al. Among authors: buckley b. Int J Mol Sci. 2021 Dec 9;22(24):13263. doi: 10.3390/ijms222413263. Int J Mol Sci. 2021. PMID: 34948058 Free PMC article.

2

6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.

Buckley BJ, Aboelela A, Minaei E, Jiang LX, Xu Z, Ali U, Fildes K, Cheung CY, Cook SM, Johnson DC, Bachovchin DA, Cook GM, Apte M, Huang M, Ranson M, Kelso MJ. Buckley BJ, et al. J Med Chem. 2018 Sep 27;61(18):8299-8320. doi: 10.1021/acs.jmedchem.8b00838. Epub 2018 Sep 7. J Med Chem. 2018. PMID: 30130401 Free PMC article.

3

The Urokinase Plasminogen Activation System in Rheumatoid Arthritis: Pathophysiological Roles and Prospective Therapeutic Targets.

Buckley BJ, Ali U, Kelso MJ, Ranson M. Buckley BJ, et al. Curr Drug Targets. 2019;20(9):970-981. doi: 10.2174/1389450120666181204164140. Curr Drug Targets. 2019. PMID: 30516104 Free PMC article. Review.

4

6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease.

Buckley BJ, Majed H, Aboelela A, Minaei E, Jiang L, Fildes K, Cheung CY, Johnson D, Bachovchin D, Cook GM, Huang M, Ranson M, Kelso MJ. Buckley BJ, et al. Bioorg Med Chem Lett. 2019 Dec 15;29(24):126753. doi: 10.1016/j.bmcl.2019.126753. Epub 2019 Oct 28. Bioorg Med Chem Lett. 2019. PMID: 31679971 Free PMC article.

5

Systematic evaluation of structure-property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride.

Buckley BJ, Aboelela A, Majed H, Bujaroski RS, White KL, Powell AK, Wang W, Katneni K, Saunders J, Shackleford DM, Charman SA, Cook GM, Kelso MJ, Ranson M. Buckley BJ, et al. Bioorg Med Chem. 2021 May 1;37:116116. doi: 10.1016/j.bmc.2021.116116. Epub 2021 Mar 23. Bioorg Med Chem. 2021. PMID: 33799173

6

Screening of 5- and 6-Substituted Amiloride Libraries Identifies Dual-uPA/NHE1 Active and Single Target-Selective Inhibitors.

Buckley BJ, Kumar A, Aboelela A, Bujaroski RS, Li X, Majed H, Fliegel L, Ranson M, Kelso MJ. Buckley BJ, et al. Int J Mol Sci. 2021 Mar 15;22(6):2999. doi: 10.3390/ijms22062999. Int J Mol Sci. 2021. PMID: 33804289 Free PMC article.

7

Novel Amiloride Derivatives That Inhibit Bacterial Motility across Multiple Strains and Stator Types.

Islam MI, Bae JH, Ishida T, Ridone P, Lin J, Kelso MJ, Sowa Y, Buckley BJ, Baker MAB. Islam MI, et al. Among authors: buckley bj. J Bacteriol. 2021 Oct 25;203(22):e0036721. doi: 10.1128/JB.00367-21. Epub 2021 Sep 13. J Bacteriol. 2021. PMID: 34516280 Free PMC article.

8

Disruption of Water Networks is the Cause of Human/Mouse Species Selectivity in Urokinase Plasminogen Activator (uPA) Inhibitors Derived from Hexamethylene Amiloride (HMA).

S El Salamouni N, Buckley BJ, Jiang L, Huang M, Ranson M, Kelso MJ, Yu H. S El Salamouni N, et al. J Med Chem. 2022 Feb 10;65(3):1933-1945. doi: 10.1021/acs.jmedchem.1c01423. Epub 2021 Dec 13. J Med Chem. 2022. PMID: 34898192

9

The Urokinase Plasminogen Activation System in Pancreatic Cancer: Prospective Diagnostic and Therapeutic Targets.

Kumar AA, Buckley BJ, Ranson M. Kumar AA, et al. Biomolecules. 2022 Jan 18;12(2):152. doi: 10.3390/biom12020152. Biomolecules. 2022. PMID: 35204653 Free PMC article. Review.

10

Urokinase plasminogen activator as an anti-metastasis target: inhibitor design principles, recent amiloride derivatives, and issues with human/mouse species selectivity.

El Salamouni NS, Buckley BJ, Ranson M, Kelso MJ, Yu H. El Salamouni NS, et al. Biophys Rev. 2022 Jan 6;14(1):277-301. doi: 10.1007/s12551-021-00921-7. eCollection 2022 Feb. Biophys Rev. 2022. PMID: 35340592 Free PMC article. Review.

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